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Product Name: Aspergillus oryzae
Other Identifiers: Koji mold, A. oryzae
Recommended Use: Food fermentation, enzyme production, research purposes
Supplier: Laboratory supply companies, biotechnology firms
Contact Details: Emergency phone numbers, address, and email for technical services
CAS Number: 554-37-6
UN Number: Not applicable for this product
Hazard Class: Biological hazard, not classified as hazardous under GHS for most applications
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Health Hazards: May cause allergic reactions in some individuals, respiratory irritation possible with dust, immunocompromised individuals may experience adverse effects
Label Elements: No pictogram required, precautionary statements necessary for possible sensitization
Symptoms of Exposure: Sneezing, coughing, skin rash, eye irritation
Environmental Hazards: No significant environmental hazards expected
Other Hazards: Spores may trigger asthma in sensitive people
Chemical Identity: Aspergillus oryzae, live or lyophilized organisms
Common Components: Spores, mycelium fragments, growth medium residues
Concentration Range: Typically provided as a pure culture or in known spore count per volume
Impurities: None intentionally added; small amounts of culture media possible
Formulation: Supplied as dry powder, pellet, or suspension
Regulatory Info: Generally Recognized as Safe (GRAS) for food applications
Inhalation: Move affected person to fresh air, monitor breathing, seek medical attention if symptoms persist
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing, consult a physician if irritation continues
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses, obtain medical advice if irritation develops
Ingestion: Rinse mouth, drink water to dilute if possible, seek medical evaluation for persistent symptoms
Most Important Symptoms: Respiratory irritation, skin rash, conjunctival redness
Immediate Medical Attention: Individuals with respiratory allergies or immunocompromised status may need professional care
Suitable Extinguishing Media: Water spray, foam, carbon dioxide, dry powder
Unsuitable Extinguishing Media: None known
Special Hazards: Organic dust from dried material can present explosion risk if airborne in significant quantities
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, particulates
Advice for Firefighters: Avoid inhalation of dust, ventilate area after extinguishing
Personal Precautions: Avoid dust formation, ventilate area, use personal protective equipment
Environmental Precautions: Prevent release of large quantities into water, soil or drains
Spill Clean-up Methods: Sweep up using methods minimizing dust, collect in suitable containers, wash area with water
Disposal: Dispose of material according to local regulations, segregate from food preparation and animal feed areas
Protective Measures: Use face mask, gloves, and protective clothing as needed
Safe Handling: Use in well-ventilated locations, minimize exposure to dust, avoid contact with skin, eyes, and clothing
Technical Measures: Keep containers tightly closed, store in cool, dry conditions, use proper labeling
Incompatibilities: Strong oxidizing agents, direct sunlight, high humidity environments
Storage Conditions: Store at recommended temperatures (often 2–8°C for lyophilized forms, or as specified), keep away from foodstuffs
Specific End Uses: Food fermentation, enzyme production, laboratory studies
Occupational Exposure Limits: None established for Aspergillus oryzae, follow good laboratory practices
Engineering Controls: Local exhaust ventilation or containment systems in case of frequent handling
Personal Protective Equipment: Laboratory coat, disposable gloves, safety glasses
Respiratory Protection: Dust mask or N95 respirator if airborne spores or powder present
Environmental Controls: Avoid creating dust clouds, use HEPA filters for vacuum cleaning
Hygiene Measures: Wash hands after handling, do not eat or drink in work areas, change out of contaminated clothing
Physical State: Dry powder, granules or liquid suspension (varies by supplier)
Color: Off-white to yellowish
Odor: Faint, earthy, fermentation odor
pH: Typically neutral in suspension
Melting/Freezing Point: Not applicable
Boiling Point: Not applicable
Solubility: Insoluble in water; forms suspension
Flammability: Powder form may present dust explosion risk
Particle Size: Spore size typically 3–6 μm
Other Characteristics: Biological, contains live or dormant spores
Chemical Stability: Stable under recommended storage conditions
Reactive Properties: Non-reactive under normal use; sensitive to temperatures above 40°C and strong oxidizers
Conditions to Avoid: Moisture, excessive heat, direct sunlight
Materials to Avoid: Strong acids, strong bases, disinfectants such as bleach
Hazardous Decomposition Products: None under normal use, combustion produces carbon oxides
Polymerization: Will not occur
Acute Toxicity: Not considered toxic by ingestion, inhalation, or dermal contact in normal laboratory use
Chronic Effects: Prolonged exposure may cause hypersensitivity in certain individuals
Respiratory Effects: Allergic reactions and asthma possible in sensitized individuals
Dermal Effects: Irritation and rash can occur in allergy-prone persons
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: No evidence from standard tests
Reproductive Toxicity: No reported risks
Ecotoxicity: No significant hazards reported; widely used in traditional fermentations
Persistence and Degradability: Organism degrades naturally in the environment
Bioaccumulation Potential: Unlikely, not fat-soluble or persistent
Mobility in Soil: Limited, survives in organic-rich environments
Other Adverse Effects: May cause overgrowth if released in excess in closed systems
Additional Notes: Essential to contain in certain settings to prevent contamination of sensitive fermentation procedures
Waste Disposal Methods: Autoclave or incinerate to kill living spores before disposal, follow local regulations
Container Disposal: Decontaminate with disinfectant, puncture containers before discarding
Special Precautions: Avoid mixing with food waste or general trash to reduce potential exposure
Recommended Procedures: Treat as biological laboratory waste; secure containers prior to final disposal
UN Number: None assigned for this product
Proper Shipping Name: Not regulated as a hazardous material for transport
Transport Hazard Class: Not classified as dangerous for road, sea, or air
Packing Group: Not assigned
Environmental Hazards: No additional requirements, but double-pack for spore-forming materials
Special Precautions for User: Seal containers to prevent dust release, avoid exposure during transfer or shipping
Classification: Generally Recognized as Safe (GRAS) for food uses (US FDA); not classed as hazardous under global chemical regulations
Other Regulation: Not subject to special labeling under OSHA, WHMIS, or EU CLP
REACH: Registration not required for pure biological material
Other National Regulations: Some countries may regulate its use in genetically modified organisms or large-scale industrial applications
User Responsibility: Follow institutional protocols and local biosafety guidelines
