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Material Safety Data Sheet: Arachidonic Acid

Identification

Product Name: Arachidonic Acid
Chemical Formula: C20H32O2
Synonyms: 5,8,11,14-Eicosatetraenoic acid
CAS Number: 506-32-1
Intended Use: Research, chemical synthesis, biochemical studies
Recommended Supplier Details: Provided by major laboratory suppliers and chemical distributors
Emergency Contact: Local poison control center or supplier safety hotline

Hazard Identification

Hazard Classification: Not classified as hazardous by GHS criteria; may cause skin, eye, and respiratory irritation
Label Elements: No pictogram or signal word required under GHS
Potential Health Effects: Skin contact may cause mild irritation; eye exposure can lead to transient discomfort; inhalation of dust may trigger respiratory irritation; ingestion not advised
Environmental Hazards: Not considered hazardous to aquatic life in small volumes
Other Hazards: Dust generation in dry form could present a minor nuisance hazard

Composition / Information on Ingredients

Chemical Name: Arachidonic Acid
Purity: Greater than 98% (typical for laboratory-grade material)
Impurities: Traces of solvents or other fatty acids may be present depending on supplier
Component Breakdown: Single ingredient substance; no complex mixture
Molecular Weight: 304.5 g/mol

First Aid Measures

Eye Contact: Rinse thoroughly with plenty of water, blinking often; seek medical attention if irritation lasts
Skin Contact: Wash with soap and water; remove contaminated clothing; monitor for redness or rash
Inhalation: Move to fresh air; assist breathing if necessary; seek medical evaluation for persistent symptoms
Ingestion: Rinse mouth with water, drink water to dilute if alert; never induce vomiting without professional guidance; call a healthcare provider
Most Important Symptoms: Mild irritation of eyes or skin, coughing if inhaled; rare cases of allergic reactions possible in sensitive individuals
Immediate Medical Attention: Only required if symptoms persist or an unusual reaction occurs

Fire-Fighting Measures

Suitable Extinguishing Agents: Dry chemical, foam, CO2, or water spray for small fires
Specific Hazards from Fire: Emits dense smoke and acrid fumes at high temperatures; combustion can release carbon monoxide and carbon dioxide
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective gear
Instructions for Firefighters: Remove containers from area if safe, cool with water mist; control runoff to prevent environmental contamination
Explosion Sensitivity: Not sensitive to impact but avoid dust clouds which might ignite under unusual circumstances

Accidental Release Measures

Personal Precautions: Wear gloves, goggles, and a dust mask for cleanup; avoid contact with skin, eyes, or clothing
Environmental Measures: Keep material out of waterways or drains; collect spillage using absorbent material and dispose of according to regulations
Cleanup Methods: Sweep up solids gently to avoid dust generation; wash area with detergent and water after removal
Special Considerations: Ventilate area to disperse airborne particles; avoid creating fine dust that can linger in the air

Handling and Storage

Safe Handling Practices: Use in well-ventilated areas, minimize dust production; handle with clean gloves to prevent contamination
Storage Conditions: Store in tightly sealed containers, protected from light, moisture, and air; keep at cool temperatures, ideally in a refrigerator at 2–8°C
Incompatible Materials: Strong oxidizers, acids, and bases should not come in contact
Hygiene Measures: Wash hands after handling and before eating, drinking, or smoking; keep working spaces free of unnecessary materials

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, or NIOSH
Engineering Controls: Use laboratory fume hoods or local exhaust if creating dust or aerosols
Personal Protection: Latex or nitrile gloves, laboratory coats, and safety goggles recommended as basic measures
Respiratory Protection: Use a dust respirator if airborne particles exceed recommended limits; not usually necessary under controlled conditions
Environmental Controls: Dispose of waste according to environmental regulations; avoid release to soil or water

Physical and Chemical Properties

Appearance: Off-white to pale yellow crystalline solid or powder
Odor: Slight fatty odor or odorless
Melting Point: Approximately 49–51°C
Boiling Point: Not readily volatile; decomposes before boiling
Solubility: Insoluble in water; soluble in ethanol, chloroform, and other organic solvents
Vapor Pressure: Negligible at room temperature
Flash Point: Estimated above 110°C
Density: About 0.94 g/cm³
pH: Not applicable for non-aqueous solid
Other Properties: Stable under recommended storage but prone to oxidation by air and light

Stability and Reactivity

Chemical Stability: Stable under normal laboratory and storage conditions
Conditions to Avoid: Excessive heat, exposure to light or air, open flames, production of dust clouds
Materials to Avoid: Strong oxidizing agents, acids, bases may cause decomposition
Hazardous Decomposition: Thermal decomposition releases carbon monoxide, carbon dioxide, possible lower aldehydes or ketones
Polymerization: Does not undergo dangerous polymerization

Toxicological Information

Routes of Exposure: Skin, eye, inhalation, ingestion
Acute Toxicity: Not acutely toxic in laboratory animals at tested doses; LD50 (oral rat) not established
Chronic Effects: No known chronic toxicity; extended exposure not recommended without protection
Irritation: Mildly irritating on contact with skin or eyes
Sensitization: No evidence of sensitization in animal studies or case reports
Carcinogenicity/Mutagenicity: No category assignment by IARC, NTP, or OSHA; data do not link to cancer, mutagenic, or reproductive effects in available studies

Ecological Information

Aquatic Toxicity: No evidence of acute toxicity in aquatic systems at typical concentrations
Environmental Persistence: Biodegradable under environmental conditions; breaks down through natural processes
Bioaccumulation Potential: Low likelihood due to rapid degradation
Mobility in Soil: Binds moderately to organic matter; not highly mobile
Other Adverse Effects: Risk to the environment considered minor for contained laboratory or industrial uses

Disposal Considerations

Waste Treatment Methods: Dispose of as chemical waste in accordance with federal, state, and local regulations
Contaminated Packaging: Triple rinse containers, dispose or recycle according to local policies
Special Instructions: Do not introduce material into public sewers or waterways; consult waste disposal coordinator for bulk quantities

Transport Information

UN Number: Not regulated as hazardous material
Transport Hazard Class: Not assigned
Packing Group: None, non-hazardous
Proper Shipping Name: Arachidonic Acid (non-regulated)
Special Precautions: Pack to avoid spillage, keep away from strong oxidizers

Regulatory Information

TSCA Inventory: Listed in Toxic Substances Control Act inventory
REACH Status: Registered in the European Union for laboratory and research use
Clean Water Act: Not specifically listed; avoid environmental release
California Proposition 65: Not listed as a carcinogen, reproductive toxin, or other health hazard
Workplace Labelling: Standard chemical identification required, no special hazard pictograms mandated
Other Regulations: Follow institutional or local chemical hygiene and safety requirements