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Product Name: Antipyrine
Synonyms: Phenazone; Analgesine
Chemical Formula: C11H12N2O
Molecular Weight: 188.23 g/mol
CAS Number: 60-80-0
Recommended Use: Laboratory reagent, pharmaceutical ingredient
Supplier Information: Name, address, contact number, emergency telephone
Emergency Overview: White crystalline powder with faint, somewhat aromatic odor
Restriction: For professional, laboratory, or industrial use
Hazard Class: Not classified as hazardous according to GHS
Health Hazards: May cause irritation to skin, eyes, and respiratory tract on prolonged exposure; toxic if ingested in large amounts
Environmental Hazards: Not considered environmentally hazardous at small quantities; large spills may affect aquatic environments
Warning Symbols: No pictogram required under GHS
Signal Word: None
Precautionary Statements: Avoid dust inhalation; prevent direct contact with skin and eyes; use appropriate protective equipment
Chemical Name: Phenazone (Antipyrine)
Concentration: 100%
CAS Number: 60-80-0
Impurities: None significant in standard laboratory or pharmaceutical forms
Inhalation: Move to fresh air, seek medical attention if irritation or symptoms develop
Skin Contact: Wash affected area with soap and water for several minutes; remove contaminated clothing
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, seek medical help if irritation persists
Ingestion: Rinse mouth, do not induce vomiting; get immediate medical attention if large quantities swallowed
Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Specific Hazards: May release toxic fumes under fire (nitrogen oxides, carbon monoxide)
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Special Procedures: Cool containers with water spray, avoid inhalation of combustion products, evacuate area if necessary
Personal Precautions: Avoid direct contact, ensure adequate ventilation, use personal protective equipment (gloves, goggles, dust mask)
Environmental Precautions: Prevent entry into drains, sewers, waterways
Methods for Cleanup: Sweep or vacuum up material, place in container for proper disposal, wash spill site with water once material removed
Safe Handling Notes: Avoid raising dust, control static electricity, minimize personnel exposure
Handling: Use in well-ventilated space, wear proper PPE, avoid contact with eyes and skin, prevent dust formation
Storage: Store in tightly sealed containers in cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and acids
Specific Requirements: Store away from foodstuffs, out of reach of unauthorized personnel; keep container tightly closed when not in use
Exposure Limits: No official TLV or PEL set; limit airborne particles as with nuisance dusts (<1 mg/m³ recommended)
Engineering Controls: Use laboratory fume hood or local exhaust; maintain general ventilation
Personal Protective Equipment: Nitrile or rubber gloves, safety goggles, laboratory coat, dust mask or respirator if dust is generated
Hygiene Measures: Wash hands and face after use; do not eat, drink, or smoke in work area
Appearance: White crystalline powder
Odor: Slightly aromatic
pH: Neutral (in aqueous solution)
Melting Point: 113–115°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, alcohol, chloroform, ether
Specific Gravity: Approximately 1.13 g/cm³
Vapor Pressure: Negligible at room temperature
Partition Coefficient: log Kow ~ 0.38
Stability: Stable under recommended storage conditions; sensitive to strong oxidizers
Chemical Stability: Stable under normal conditions
Possibility of Hazardous Reactions: Reacts with strong oxidizing agents, acids
Incompatible Materials: Strong oxidizers, mineral acids
Hazardous Decomposition Products: May emit nitrogen oxides, carbon monoxide and carbon dioxide during thermal decomposition
Acute Toxicity: LD50 (oral, rat) ~ 1,820 mg/kg
Skin/Eye Irritation: Mild to moderate irritant
Chronic Effects: May cause blood abnormalities (methemoglobinemia) if ingested in large or repeated doses
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Dizziness, headache, cyanosis, skin or mucous membrane irritation possible with large, repeated, or accidental exposures
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Ecotoxicity: No data for acute toxicity to fish, invertebrates, or plants; not likely to bioaccumulate
Persistence and Degradability: Expected to biodegrade in environment, but rate unknown
Mobility: Moderately mobile in soil and water systems
Bioaccumulation Potential: Low potential due to low log Kow value
Other Adverse Effects: Large spills may temporarily affect microbial action in aquatic systems
Waste Disposal: Dispose of as hazardous chemical waste in accordance with local, regional, and national regulations
Contaminated Packaging: Empty containers should be triple rinsed and disposed of through approved waste management facilities
Safe Practices: Do not discharge unused material into surface water, sewage system, or ground
UN Number: Not regulated for transport
Transport Hazard Class: Not classified as dangerous goods
Packing Group: Not assigned
Proper Shipping Name: Antipyrine
Environmental Hazards: Not classified as marine pollutant
Transport Precautions: Avoid operations releasing dust to air during loading, unloading, or transport; use closed containers
US TSCA status: Listed
EC List: Listed
REACH Status: Registered
SARA 313: Not subject to reporting
WHMIS Classification: Not regulated
Other Relevant Regulations: Handle according to OSHA, NIOSH, and local occupational safety rules
