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Product Name: Ampicillin Sodium
Chemical Name: 2S,5R,6R-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt
CAS Number: 69-52-3
Recommended Uses: Antibiotic formulation for medical and laboratory applications
Supplier Details: Name, address, and emergency contact details required by local guidelines
Emergency Contact: Local poison control center or emergency medical response
Classification: Harmful if inhaled or swallowed, possible allergen with potential for skin and respiratory sensitization
Main Hazards: Risk of allergic reactions in sensitive individuals, irritation to eyes, skin, mucous membranes, and respiratory tract
GHS Label Elements: Warning symbol, hazard statement (H302, H334), and precautionary statements
Other Risks: Not considered flammable, but dust can form explosive mixtures with air under rare circumstances
Chemical: Ampicillin Sodium
Synonyms: Sodium ampicillin, D-(-)-α-Aminobenzylpenicillin sodium
Formula: C16H18N3NaO4S
Concentration: Pure or pharmacopeial grade, commonly above 95%
Impurities: May contain small traces of related substances or process residues
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, seek medical advice
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, consult a physician for persistent irritation
Inhalation: Move to fresh air, keep at rest, and obtain medical attention for difficulty breathing or symptoms of allergic response
Ingestion: Rinse mouth, do not induce vomiting, seek medical help for symptoms or accidental large exposure
Symptoms: Rash, itching, trouble breathing, swelling, particularly in known penicillin-allergic individuals
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Special Hazards: Thermal decomposition may generate toxic gases (nitrogen oxides, sulfur oxides, carbon oxides)
Advice for Firefighters: Wear self-contained breathing apparatus, protective clothing, and avoid inhalation of smoke
Other Precautions: Cool containers near fire with plenty of water to prevent rupture
Personal Precautions: Wear appropriate protective equipment to avoid contact with skin, eyes, or clothing
Spill Cleanup: Sweep up and shovel gently to minimize dust; avoid releasing into drains or open water
Environmental Precautions: Prevent further leakage or spillage, contain with sand or suitable material
Disposal: Place collected material in closed container for proper disposal per local regulations
Safe Handling: Use in well-ventilated areas, avoid breathing dust, and minimize dust generation
Hygiene Measures: Wash hands after handling and before eating, drinking, or smoking
Storage Conditions: Store tightly sealed in a dry, cool location, protected from light and incompatible substances
Incompatibilities: Avoid acids, oxidizing agents, and materials sensitive to sodium compounds
Special Storage Requirements: Label containers clearly, restrict access to trained personnel
Exposure Limits: No OSHA or ACGIH exposure limits set for ampicillin sodium
Engineering Controls: Use local exhaust ventilation to control airborne dust
Personal Protection: Safety goggles, chemical-resistant gloves, laboratory coat, respiratory protection if exposure exceeds limits
Environmental Controls: Contain and properly treat process waste and laboratory effluent
Other Recommendations: Emergency eyewash and shower stations recommended in work area
Appearance: White to off-white crystalline powder
Odor: Odorless or slightly medicinal
Solubility: Freely soluble in water, practically insoluble in alcohol and most organic solvents
pH (1% solution): 8.0–10.0
Melting Point: Decomposes above 200°C
Molecular Weight: 371.39 g/mol
Other Data: Hygroscopic, stable under recommended storage, sensitive to strong acids and bases
Chemical Stability: Stable under normal conditions and storage guidelines
Reactivity: Reacts with strong oxidizers and acids, decomposes at high temperature
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon oxides
Polymerization: Will not occur under normal handling
Conditions to Avoid: High moisture, extreme heat, exposure to light and incompatible substances
Acute Toxicity: Oral LD50 (rat): 10,000–12,000 mg/kg; Intraperitoneal LD50 (rat): 6,000 mg/kg
Chronic Effects: Prolonged exposure can lead to sensitization, allergic reactions, and possible impact on normal microbiota
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Reproductive Toxicity: No known reproductive hazards under recommended use
Additional Data: Significant allergic potential for individuals sensitive to beta-lactam antibiotics
Aquatic Toxicity: Low general toxicity; overuse or improper disposal may contribute to antibiotic resistance in water systems
Environmental Fate: Moderate persistence in soil and water, breaks down gradually by hydrolysis and microbial activity
Bioaccumulation Potential: Low,
Other Risks: Release into environment can select for resistant bacteria and disrupt microbial ecosystems
Further Information: Avoid letting substance enter surface water, waste water, or soil
Product Disposal: Burn in a chemical incinerator equipped with afterburner and scrubber, or follow local authority guidance
Contaminated Packaging: Containers must be emptied completely and triple-rinsed before recycling or disposal
Sewage Disposal: Do not discharge into drains or the environment
Legal Requirements: Follow federal, state, and local environmental control regulations
Other Advice: Consult a licensed professional for chemical waste disposal
UN Number: Not classified as a hazardous material for transport
Proper Shipping Name: Ampicillin Sodium
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Transport Precautions: Shipped in well-sealed containers, avoid physical damage, and keep away from incompatible substances or sources of ignition
Labeling: Must comply with local hazard communication and labeling requirements
Inventory Status: Listed in national and international chemical inventories (such as TSCA, EINECS/ELINCS)
Regulation: Controlled as a pharmaceutical compound in many jurisdictions, subject to prescription and distribution laws
Workplace Safety: OSHA Laboratory Standard applies, as well as Chemical Hygiene Plan provisions
Other Requirements: Reportable under certain environmental regulations if released in significant quantity; employee training on hazards, personal protection, and spill response is expected
