© 2026 Alchemist Worldwide Ltd,
All Right Reserved
Product Name: Aminopyrine
Chemical Name: 4-Dimethylaminoantipyrine
Synonyms: Amidopyrine, Dimethylaminoantipyrine
CAS Number: 58-15-1
Molecular Formula: C13H17N3O
Intended Use: Laboratory reagent, discontinued use in medicine
Manufacturer Details: Provided on request from supplier
Emergency Contact: Local emergency number for hazardous chemical exposure
Recommended Restrictions: For research and industrial applications only; not for drug, food, or household use
Classification: Harmful if swallowed, causes skin and eye irritation, may cause allergic skin reaction, suspected of causing genetic defects
GHS Label Elements: Exclamation mark, Health hazard
Hazard Statements: H302: Harmful if swallowed, H315: Causes skin irritation, H317: May cause allergic skin reaction, H319: Causes serious eye irritation, H341: Suspected of causing genetic defects
Precautionary Statements: Do not breathe dust or fumes; wash hands thoroughly after handling; use personal protective equipment; if on skin, wash with plenty of soap; if in eyes, rinse carefully with water;
Target Organs: Liver, blood, bone marrow
Additional Risks: May cause methemoglobinemia and agranulocytosis after ingestion or prolonged exposure
Chemical Component: Aminopyrine
Concentration: 100%
Molecular Weight: 231.3 g/mol
Impurities or Stabilizers: No significant impurities reported for laboratory-grade material
Other Ingredients: None present
Inhalation: Move to fresh air, keep at rest, seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, wash skin with plenty of water and soap, get medical advice on persistent irritation
Eye Contact: Rinse immediately with water for at least 15 minutes, keep eyelids open, seek medical assessment if irritation remains
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical assistance, show product label if possible
Most Important Symptoms: Headache, dizziness, blue skin (cyanosis), allergic reactions, anemia
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, alcohol-resistant foam
Specific Hazards Arising from the Chemical: Emits toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide on combustion or decomposition
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective clothing must be worn
Firefighting Instructions: Avoid inhaling vapors or fumes, contain runoff to prevent environmental contamination, cool containers with water spray
Personal Precautions: Use gloves, safety goggles, avoid contact with skin and eyes, avoid breathing dust
Environmental Precautions: Prevent spillage from entering drains, surface and groundwater, avoid release into the environment
Cleanup Methods: Wear appropriate PPE, sweep up solids carefully to prevent dust, place in sealed container for proper disposal, ventilate the area thoroughly
Handling: Use in a well-ventilated area, minimize dust generation, avoid contact with skin, eyes, and clothing, wash thoroughly after handling, keep away from food and beverages
Storage: Store in tightly sealed containers in a cool, dry place, protect from light and moisture, keep container upright, avoid incompatible materials like oxidizers, restrict access to trained personnel
Engineering Controls: Employ local exhaust ventilation, provide eyewash stations and safety showers near handling area
Personal Protective Equipment: Use NIOSH/MSHA-approved respirator for dust, chemical-resistant gloves (nitrile or neoprene), safety goggles, lab coat or appropriate protective clothing
Hygiene Measures: Remove contaminated clothing, wash hands before eating or drinking, do not smoke or consume beverages in handling areas
Occupational Exposure Limit: Not established in major jurisdictions; use good industrial hygiene judgment
Appearance: White to pale yellow crystalline powder
Odor: Odorless
Melting Point: 110–113°C
Boiling Point: Not determined
Solubility: Soluble in water, alcohol, and ether
Density: Approximately 1.33 g/cm³
pH: Not applicable (solid form)
Flash Point: Not readily flammable
Vapor Pressure: Not significant at room temperature
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizing agents
Decomposition Products: Toxic gases such as nitrogen oxides, carbon oxides produced from fire or heating
Hazardous Polymerization: No dangerous polymerization reported
Incompatible Materials: Strong acids, bases, and oxidizers can cause hazardous reactions
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 in rat: 900 mg/kg; can cause liver and blood complications
Chronic Effects: Repeated oral or dermal exposure may cause immune system depression, risk of agranulocytosis (especially in genetically predisposed individuals)
Symptoms: Nausea, fatigue, breathing problems, blue discoloration of lips or skin, allergic reaction
Carcinogenicity: Not classified as carcinogenic by IARC, ACGIH, NTP, or OSHA
Mutagenicity: Evidence suggests genetic toxicity in cell assays
Reproductive Effects: No clear evidence for reproductive toxicity
Ecotoxicity: Toxic to aquatic organisms by acute and chronic mechanisms
Persistence and Degradability: Not rapidly biodegradable under standard conditions; may persist in aquatic environments
Bioaccumulative Potential: Moderate potential; can be absorbed by aquatic organisms
Mobility in Soil: Water-soluble, may leach to groundwater
Other Adverse Effects: Avoid release to environment due to potential risk to aquatic life
Disposal Methods: Dispose through licensed chemical waste contractor; incinerate in approved facility, prevent from entering water or drain systems
Special Precautions: Contaminated packaging and cleanup materials to be treated as hazardous waste, comply with local, regional, and national disposal regulations
Empty Containers: Decontaminate before reuse or disposal according to regulatory guidance
UN Number: Not assigned for small laboratory quantities
Proper Shipping Name: Chemical, not otherwise specified
Transport Hazard Class: Not regulated for ground, air, or sea transport in small quantities
Packing Group: Not specified for small laboratory use
Special Transport Precautions: Secure containers to prevent movement, avoid damage to packaging, keep separate from food and incompatible materials
OSHA Status: Hazardous chemical as defined in OSHA Hazard Communication Standard
TSCA Status: Listed in US Toxic Substances Control Act inventory
EU Regulation: Listed under REACH; restricted or discontinued use for pharmaceuticals
SARA Title III: Not listed as an extremely hazardous substance
WHMIS (Canada): D2B – Toxic material causing other toxic effects
Other Regulations: Subject to workplace and environmental safety rules; not allowed as a medication in many countries due to risk of severe adverse health effects
