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Material Safety Data Sheet: Alpha-Amylase

Identification

Product Name: Alpha-Amylase
Chemical Family: Enzymes
Synonyms: 1,4-alpha-D-glucan glucanohydrolase
CAS Number: 9000-90-2
Uses: Starch conversion in food processing, brewing, detergents, textiles, paper industries
Supplier Details: Manufacturer contact, address, emergency phone number

Hazard Identification

GHS Classification: Sensitizer (respiratory, skin), Eye irritant
Signal Word: Warning
Hazard Statements: May cause allergy or asthma, respiratory irritation, skin or eye irritation
Precautionary Statements: Avoid inhalation, wear protective equipment, wash after handling
Symptoms of Exposure: Sneezing, coughing, skin redness, eye discomfort

Composition / Information on Ingredients

Alpha-Amylase (Active Ingredient): 1–20%
Carrier (e.g., maltodextrin, sodium chloride): 80–99%
Preservative (if present): Trace amounts
Stabilizers: As required for formulation stability

First Aid Measures

Inhalation: Move to fresh air, seek medical attention if symptoms persist
Skin Contact: Rinse thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, continue rinsing, consult physician if irritation continues
Ingestion: Rinse mouth, drink water, seek medical help if feeling unwell
Advice for Rescuers: Wear nitrile gloves and respiratory protection to avoid exposure

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Direct water jet (may spread powder)
Specific Hazards: Forms combustible dust clouds, decomposes emitting irritating fumes under fire
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Special Procedures: Cool container with water spray to prevent pressure buildup, block runoff to prevent environmental contamination

Accidental Release Measures

Personal Precautions: Wear gloves, goggles, suitable mask to prevent inhalation and contact
Environmental Precautions: Keep out of drains and open water sources, contain spill
Cleanup Methods: Sweep up carefully to avoid dust, use damp cloth or vacuum with HEPA filter, discard materials in proper waste container
Preventative Actions: Ventilate area thoroughly before reentry, tag area as hazardous until clean

Handling and Storage

Handling: Avoid aerosol formation, wear appropriate personal protective equipment, maintain good industrial hygiene
Storage Conditions: Store in closed, labeled containers in cool, dry, well-ventilated area, away from strong acids and oxidizers
Safe Practices: Prevent dust accumulation, handle away from incompatible substances
Hygiene Recommendations: Wash hands and exposed skin before eating or drinking, keep work clothing separate from non-work clothing

Exposure Controls and Personal Protection

Exposure Limits: Occupational limits not established specifically for enzyme powders; limit airborne concentrations as low as reasonably achievable
Engineering Controls: Local exhaust ventilation, dust extraction, avoid confined areas
Personal Protective Equipment: NIOSH-approved respirator for particulates, safety goggles or face shield, nitrile or latex gloves, protective clothing
Environmental Controls: Proper disposal systems for ventilation exhaust, spill containment for waste enzyme material

Physical and Chemical Properties

Appearance: Off-white to beige powder or granulated solid
Odor: Slight, characteristic enzyme odor
Odor Threshold: Not established
pH (1% solution): 4.5–7.5
Melting/Freezing Point: Not applicable
Boiling Point: Not applicable
Solubility: Readily soluble in water
Vapor Pressure: Not applicable
Decomposition Temperature: Above 60°C may cause gradual enzyme inactivation
Explosive Properties: Dust may form explosive mixtures with air

Stability and Reactivity

Stability: Stable under ambient conditions if kept dry and sealed
Reactivity: Non-reactive with common substances under normal use
Incompatible Materials: Strong acids, oxidizers, alkalis can destroy enzyme activity
Hazardous Decomposition Products: Burning creates carbon oxides, nitrogen oxides, enzyme breakdown products
Polymerization: Will not occur under recommended storage or use

Toxicological Information

Routes of Exposure: Inhalation, skin and eye contact
Acute Effects: Irritation of mucous membranes, skin, eyes; possible sensitization
Chronic Effects: Repeated inhalation can cause allergic respiratory reactions, asthma-like symptoms
Carcinogenicity: Not classified as a carcinogen
Mutagenicity / Teratogenicity: No evidence from available studies
Symptoms of Overexposure: Persistent cough, shortness of breath, dermatitis in sensitive individuals

Ecological Information

Ecotoxicity: Low risk to aquatic organisms at release levels typical for normal operations
Persistence and Degradability: Rapidly biodegradable, decomposes into amino acids and sugars
Bioaccumulation Potential: Not expected to bioaccumulate
Aquatic Release Measures: Avoid discharge to surface water, prevent entry to storm drains
Other Adverse Effects: None known from current studies

Disposal Considerations

Waste Disposal: Place enzyme waste in clearly labeled, tightly sealed containers, dispose through licensed hazardous waste contractor
Container Disposal: Rinse thoroughly, recycle or dispose following local, regional, national regulations
Avoid Disposal in: Open waterways, soil, regular trash
Unused Product: Return to manufacturer or approved facility if possible, do not flush or incinerate without permission

Transport Information

UN Number: Not regulated as dangerous goods for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: None reported under normal conditions
Special Precautions for Transport: Keep container dry, protected from moisture, handle gently to avoid breakage and spillage

Regulatory Information

Labelling Requirements: Pictograms, signal words, precautionary statements per GHS
TSCA Status: Listed
REACH Registration: Complies with EU requirements
OSHA Hazard Communication: This material falls under OSHA Hazard Communication Standard
Other Local/International Regulations: Conforms to country-specific workplace safety, environmental handling, and waste disposal guidelines where used or transported