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Material Safety Data Sheet for Alitame

Identification

Product Name: Alitame
Chemical Name: L-α-Aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide
Common Synonyms: Aspartame analog, APM-2
Chemical Formula: C14H25N3O4S
Product Description: High-intensity sweetener, white to off-white crystalline powder
CAS Number: 80863-62-3
Recommended Use: Food additive, table-top sweetener, beverage ingredient
Supplier: [Supplier Name], [Supplier Address], [Supplier Contact Information]
Emergency Contact: [Phone Number]

Hazard Identification

GHS Classification: Not classified as hazardous under GHS standards
Primary Hazards: Low acute toxicity; dust may irritate eyes, skin, and respiratory tract
Signal Word: None required
Hazard Statements: May cause slight irritation if particles contact eyes or skin. Inhalation of dust could irritate respiratory passages.
Precautionary Statements: Avoid breathing dust. Use personal protective equipment. Wash hands thoroughly after handling.

Composition / Information on Ingredients

Chemical Substance: Alitame
Purity: >98%
Impurities: Trace organic and inorganic contaminants below regulatory thresholds
Additives: None
Ingredients contributing to hazard: No component present at levels classified as hazardous

First Aid Measures

Inhalation: Remove person to fresh air. Provide respiratory support if breathing is difficult. Seek medical attention for persistent symptoms.
Skin Contact: Remove contaminated clothing. Wash exposed skin with soap and water. Get medical help if irritation develops.
Eye Contact: Flush with plenty of running water for at least fifteen minutes, lifting eyelids occasionally. Remove contact lenses if easy to do. Seek medical attention if discomfort persists.
Ingestion: Rinse mouth. Do not induce vomiting. Drink water in small sips if conscious. Seek medical advice for any symptoms.

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Unsuitable Media: High-pressure water streams, which may scatter powder
Special Fire Hazards: Combustion releases carbon oxides, nitrogen oxides, sulfur oxides
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective clothing
Firefighting Instructions: Keep containers cool with water spray to prevent pressure build-up. Move undamaged containers from fire area if safe.

Accidental Release Measures

Personal Precautions: Wear protective gloves, dust mask, goggles. Avoid creating dusty conditions.
Environmental Precautions: Prevent further spillage; avoid discharge into drains, soil, or waterways.
Spill Clean-up: Sweep up powder without generating dust. Collect and place in labeled waste containers for disposal. Wash residual material away with water.
Emergency Procedures: Ventilate area; evacuate unnecessary personnel.

Handling and Storage

Handling: Keep packaging tightly closed. Minimize dust generation. Wash hands before eating, drinking, or smoking.
Storage Conditions: Store in a dry, cool, well-ventilated location. Protect from moisture, direct sunlight, sources of ignition, and incompatible substances.
Storage Temperature: Below 25°C recommended for product integrity.
Incompatible Materials: Strong oxidizers, acids, and bases.
Packaging Materials: Use original or approved containers resistant to moisture and chemical attack.

Exposure Controls and Personal Protection

Occupational Exposure Limit: Not established by OSHA, ACGIH, or other regulatory bodies
Engineering Controls: Local exhaust ventilation, process enclosures, dust collection systems
Personal Protective Equipment: Dust mask or particulate respirator (P2 or N95), chemical resistant gloves (nitrile or latex), safety glasses with side shields, laboratory coat
Hygiene Measures: Wash hands after handling. Prohibit eating, drinking, and smoking in work area.
Environmental Controls: Prevent uncontrolled release to environment. Use proper containment for bulk storage.

Physical and Chemical Properties

Appearance: White or almost white crystalline powder
Odor: Practically odorless
Odor Threshold: Not determined
pH: 5–7 (1% aqueous solution)
Melting Point: 86–95°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Negligible under ambient conditions
Solubility: Freely soluble in water, sparingly soluble in ethanol, insoluble in most organic solvents
Density: 1.25–1.30 g/cm³
Partition Coefficient (log Kow): Not available
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Thermal Decomposition: Decomposes at elevated temperatures, releasing irritating or toxic gases
Conditions to Avoid: Excess heat, moisture, sunlight, strong acids, strong bases
Hazardous Reactions: No dangerous reactions reported under normal uses
Incompatible Materials: Oxidizing materials, strong acids, bases
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon monoxide and dioxide, small organic compounds

Toxicological Information

Acute Toxicity: Low oral toxic effects; estimated LD50 (oral, rat) >2000 mg/kg
Skin and Eye Irritation: May cause mild irritation on contact
Respiratory Irritation: Inhaled dust may cause temporary symptoms such as coughing and sneezing
Chronic Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in animal studies
Sensitization: Not considered a sensitizer for skin or respiratory exposure
Other Toxic Effects: No significant systemic effects reported at occupational exposure levels

Ecological Information

Aquatic Toxicity: Low toxicity for aquatic organisms based on available data
Persistence and Degradability: Moderately biodegradable in soil and water environments
Bioaccumulation Potential: Significant accumulation not expected due to chemical structure
Mobility in Soil: Mobile in aqueous phase; expected to partition to water rather than soil or sediment
Other Effects: Large spills may temporarily increase chemical oxygen demand in waterways

Disposal Considerations

Waste Disposal Methods: Treat as non-hazardous waste; dispose of in accordance with local, state, and federal regulations
Recycling Potential: Not appropriate for recycling due to food-grade purity requirements
Container Disposal: Rinse thoroughly, render unusable, and send for landfill or incineration with proper documentation
Precautions: Prevent bulk disposal to surface water, septic systems, or uncontrolled environments

Transport Information

UN Number: Not regulated for transport
Proper Shipping Name: Alitame
Transport Hazard Class: Not classified as dangerous
Packing Group: Not applicable
Marine Pollutant: Not listed
Special Transport Precautions: Protect containers from physical damage and moisture during transport

Regulatory Information

Global Inventories: Listed in national chemical inventories including the United States (TSCA), Europe (EINECS), Australia (AICS), Canada (DSL)
Food Additive Status: Approved as a sweetener in several countries
Workplace Regulations: No specific occupational exposure limits set by OSHA, ACGIH, or EU OSHA
Labeling Requirements: No mandatory hazard symbols required under GHS
Other Data: Not subject to regulatory control as a hazardous substance or dangerous good; users remain responsible for compliance with all relevant laws and standards