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Product Name: Albendazole
Chemical Formula: C12H15N3O2S
CAS Number: 54965-21-8
Synonyms: Methyl 5-(propylthio)-2-benzimidazolecarbamate
REACH Registration Number: 01-2119980569-13-0000
Recommended Use: Anthelmintic for veterinary and human medicine
Manufacturer Details: Access through safety compliance contact, reference global pharmacopoeia for source
Emergency Contact: Refer to regional poison centers and local health authorities
Classification: Hazardous according to GHS criteria
Physical Hazards: None under normal handling conditions
Health Hazards: May be harmful if swallowed, inhaled, or absorbed through skin; Possible reproductive toxin; Causes irritation to eyes, skin, and respiratory tract
Environmental Hazards: Highly toxic to aquatic organisms with long-lasting effects
Label Elements: Warning, toxic symbol, environmental dangerous symbol
Signal Word: Warning
Hazard Statements: Suspected of damaging fertility or the unborn child, causes skin irritation, causes serious eye irritation, toxic to aquatic life
Chemical Name: Albendazole
Concentration: ≥98% (pure ingredient, typical for laboratory and industrial use)
Impurities: Traces of related benzimidazole compounds (specifications provided by supplier)
Additive Components: None in pure form; consult formulation for tablets or suspensions for excipients
Inhalation: Move exposed person to fresh air, provide oxygen or artificial respiration as needed, consult medical advice for continued symptoms
Skin Contact: Remove contaminated clothing, wash affected skin thoroughly with soap and water
Eye Contact: Rinse eyes immediately with plenty of running water for 15 minutes, seek prompt medical attention for continued irritation
Ingestion: Do not induce vomiting unless directed by medical personnel, rinse mouth thoroughly, seek medical advice especially if symptoms occur or large amounts ingested
Important Symptoms: Nausea, headache, dizziness, allergic reactions, abdominal pain, rare cases of bone marrow suppression reported
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Avoid high-pressure water jets
Special Hazards: Combustion releases hazardous fumes such as nitrogen oxides, sulfur oxides, carbon monoxide
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective clothing
Precautions: Move containers from fire area if safe, keep fire-exposed containers cool using water spray, avoid breathing fire gases
Personal Precautions: Wear appropriate personal protective equipment including respiratory protection, avoid dust formation
Environmental Precautions: Prevent release into drains, watercourses, or soil
Containment: Sweep up spilled material carefully, minimize dust, collect in suitable container for disposal
Cleaning Methods: Wash exposed area with water and detergent after material is removed, properly ventilate affected area
Handling: Use in well-ventilated areas, avoid breathing dust or contact with skin and eyes, do not eat or drink during handling
Storage Conditions: Store tightly closed in cool, dry, well-ventilated place, keep away from incompatible materials such as strong oxidizing agents and acids
Special Considerations: Prevent formation and accumulation of dust, protect from light and moisture, maintain proper labeling
Exposure Limits: No specific OSHA, ACGIH, or EU workplace exposure limits for albendazole; general dust exposure limits apply (10 mg/m3 for nuisance dust)
Engineering Controls: Ensure local exhaust ventilation at points of dust generation, fume hood for laboratory handling
Personal Protective Equipment: Use chemical resistant gloves (nitrile, PVC), lab coat or protective clothing, safety eye goggles, NIOSH/MSHA-approved respirators where exposure risk exists
Hygiene Measures: Wash hands before breaks and at end of work, remove contaminated clothing before leaving work area, avoid contact with skin and eyes
Appearance: White to off-white crystalline powder
Odor: Odorless or faint
pH: Poorly soluble in water, forms suspension with neutral to weak basic pH
Melting Point: 208-210°C
Boiling Point: Decomposes before boiling
Solubility: Less than 5 mg/L in water at room temperature, soluble in DMF, DMSO, and slightly in ethanol
Vapor Pressure: Not significant at room temperature
Partition Coefficient (log Kow): 2.6
Flash Point: Data not available
Relative Density: 1.30 g/cm³ at 20°C
Other Data: Stable against light when stored properly, not explosive
Chemical Stability: Stable under normal use and storage conditions
Reactivity: Not reactive with common substances at room temperature
Hazardous Reactions: Avoid contact with strong acids, bases, and oxidizing agents; may decompose at high temperatures producing toxic fumes
Polymerization: Will not occur
Conditions to Avoid: Excess heat, sunlight, improper storage humidity
Acute Toxicity: Oral LD50 in rats around 1,320 mg/kg; relatively low acute toxicity but high doses may cause toxicity in mammals
Skin Irritation: May cause mild irritation with prolonged or repeated exposure
Eye Irritation: Causes eye irritation
Carcinogenicity: Not classified by IARC; some animal studies suggest potential carcinogenicity with prolonged, high-dose exposure
Reproductive Effects: Possible hazard to reproduction and fetal development based on animal studies
Sensitization: May cause allergic skin reactions
Other Effects: Rare reports of bone marrow suppression, reversible liver enzyme elevation observed in some treated individuals
Aquatic Toxicity: Highly toxic to fish and aquatic invertebrates; LC50 (96 h) in Daphnia magna below 1 mg/L
Persistence and Degradability: Low biodegradability; moderate to persistent in soil and water, may bioaccumulate
Bioaccumulation: Potential exists based on log Kow
Mobility in Soil: Low mobility due to low water solubility
Other Hazards: At trace levels, can disrupt aquatic food webs, risk to non-target organisms (especially aquatic species)
Disposal Considerations: Minimize environmental introduction, always treat dust and residues as hazardous waste
Product Disposal: Dispose of as hazardous chemical waste in accordance with local, regional, and national regulations
Contaminated Packaging: Treat as hazardous material, ensure thorough cleaning before recycling or disposal
Precautions: Do not discharge to surface water, sewer, or soil
Recommended Methods: Incineration in licensed facility preferred, physical removal followed by destruction to minimize residue
UN Number: Not regulated under current international transport rules for pharmaceuticals (IATA, ADR, IMDG), but verify local shipment compliance
Proper Shipping Name: Albendazole, non-hazardous for most forms if pure
Hazard Class: None assigned
Packing Group: None assigned
Special Precautions: Avoid release during transport, keep tightly sealed in primary containers, consult carrier for safe packaging protocols
Environmental Hazards: May be regulated as marine pollutant if bulk transported
Inventory Listings: Listed on Chemical Inventories such as TSCA, EINECS, AICS depending on jurisdiction
EU Regulation: Classified under REACH, may fall under restrictions for substances of very high concern (SVHC) for reproductive toxicity
US Regulation: Not listed as hazardous under SARA Title III or CERCLA, subject to FDA and EPA rules for pharmaceuticals and pesticides
Canada: Listed on DSL, primarily regulated as veterinary and human medicine
Global: Compliance required with GHS for labeling, safety, and safe handling instructions, always check national regulations before use
Other: Packaging, waste, and accidental release regulated by national hazardous waste laws, safety communication required following ILO and WHO standards
