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Material Safety Data Sheet: Active Peptide

Identification

Product Name: Active Peptide
Recommended Use: Laboratory reagent, research and development, clinical studies
Manufacturer: See product insert or label for company details and 24-hour emergency contact
Address: Supplied by manufacturer, information located on original packaging
Telephone: Emergency and information numbers provided by supplier
Synonyms: Biologically active oligopeptide, custom synthetic peptide
CAS Number: Available from Certificate of Analysis provided by producer
Product Code: As printed on label and accompanying documents

Hazard Identification

Hazard Classification: Not classified as hazardous under GHS criteria if handled within standard laboratory procedures
Physical Hazards: Peptides in lyophilized powder or solution may create dust when handled, inhalation of powders can irritate respiratory tract
Health Hazards: Potential allergen for sensitized individuals, may cause mild irritation to eyes, skin, respiratory tract
Signal Word: No specific signal word assigned
Major Symptoms: Eyes: Redness and discomfort; Skin: Redness, mild itching; Inhalation: Coughing or throat irritation; Ingestion: Abdominal discomfort if ingested in quantity
Pictograms: None required according to latest safety standards
Precautionary Statements: Avoid breathing dust, prevent contact with eyes and skin, wash with water after handling
Other Hazards: No evidence for carcinogenicity, mutagenicity, or reproductive toxicity from current research

Composition / Information on Ingredients

Chemical Identity: Mixture of amino acids forming specific peptide sequence
Concentration: Proprietary, detailed on technical specification sheet
Formulation: Highly purified, usually over 95% purity by HPLC
Impurities: Traces of trifluoroacetic acid (TFA), possible residual solvents from synthesis, protected within limits set by applicable standards
Other Components: Lyophilized with or without stabilizing excipients (e.g. mannitol, trehalose, acetate buffer) depending on product form
Ingredient Disclosure: Not considered hazardous according to regulatory definitions for laboratory-grade peptides

First Aid Measures

General Advice: Remove from exposure area, seek medical attention for severe or ongoing symptoms
Inhalation: Move person to fresh air, keep at rest, seek medical attention for persistent irritation or difficulty breathing
Eye Contact: Rinse immediately with water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical attention for continued discomfort
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, hydrocortisone cream may help mild irritation
Ingestion: Wash mouth, give small amounts of water, do not induce vomiting, consult doctor if large amounts consumed or symptoms develop
Note to Physician: Treat symptomatically, monitor for allergic reactions

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemicals, carbon dioxide, or foam
Unsuitable Media: Do not use high pressure water stream which may spread powder
Hazards from Burning: Decomposition releases nitrogen oxides, carbon oxides, and traces of organic vapors
Protective Equipment: Self-contained breathing apparatus and full protective clothing recommended for large fires
Specific Procedures: Prevent runoff to sewers or waterways, cool containers exposed to heat, evacuate area if fire grows large

Accidental Release Measures

Personal Precautions: Reduce dust formation, ventilate area, use appropriate PPE such as protective gloves, laboratory coat, and eyewear
Environmental Precautions: Avoid allowing material to enter the environment, prevent dust spreading with damp towels or absorbent materials
Cleanup Methods: Sweep or vacuum using HEPA filtration if available, place residue in leak-proof waste containers, wash area with water and mild detergent, ventilate room
Notification Procedures: Report significant spills to facility safety representative as defined by institutional policy

Handling and Storage

Handling: Minimize dust and aerosol generation, handle in well-ventilated laboratory spaces, do not eat, drink, or smoke when working with peptide powders
Storage: Store in sealed vials at -20°C for long term stability, keep away from heat and sources of ignition, avoid moisture exposure
Packaging Materials: Use original containers, keep tightly sealed after opening, secondary containment recommended if large volumes are stored
Incompatibilities: Avoid strong acids, bases, and oxidizing agents that can degrade peptide integrity

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation or work in a chemical fume hood, systems must provide adequate air changes and reduce airborne particulates
Exposure Limits: No occupational exposure limits established for peptides, observe good laboratory safety standards
Personal Protective Equipment: Nitrile gloves, laboratory coat, splash-proof safety goggles or face shield for larger quantities, NIOSH-certified dust mask for bulk handling
Hygiene Measures: Wash hands after use, change contaminated clothing, avoid contact with eyes and skin, do not eat or drink in the work area

Physical and Chemical Properties

Appearance: White to off-white lyophilized powder or clear solution depending on the package
Odor: No noticeable odor
pH: Usually neutral in solution unless formulated differently
Melting Point: Not applicable or decomposes before melting
Boiling Point: Not applicable
Flash Point: Not flammable
Solubility: Soluble in water, dilute acetic acid, or buffer solutions per manufacturer’s recommendations
Vapor Pressure: Not volatile
Specific Gravity/Density: Approximately 1.3 – 1.6 g/cm³
Partition Coefficient: Not determined for technical peptide
Decomposition Temperature: Typically above 200°C
Evaporation Rate: Not applicable for solids and highly stable solutions

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions (frozen or refrigerated, dry, protected from light)
Conditions to Avoid: Moisture, prolonged exposure to air, high temperatures degrade peptide chains
Materials to Avoid: Strong oxidizers, acids, or bases which can fragment or denature peptide
Hazardous Decomposition Products: Heating generates carbon oxides, nitrogen compounds, potential low-toxic organic fragments
Reactivity: No hazardous reactions in standard laboratory or research applications

Toxicological Information

Acute Toxicity: Low oral and dermal toxicity expected based on peptide structure and literature references
Routes of Exposure: Eyes, skin, inhalation, ingestion
Skin Corrosion/Irritation: Limited evidence of irritation, lower risk compared to many synthetic compounds
Eye Damage/Irritation: May cause mild transient discomfort, standard rinse usually sufficient
Respiratory Sensitization: Possible in susceptible individuals if handled as airborne powder
Chronic Effects: No evidence of carcinogenic, mutagenic, teratogenic, or reproductive effects from standard laboratory use
Additional Data: Specific peptide sequences not listed on IARC, ACGIH, NTP, or OSHA carcinogen lists

Ecological Information

Eco-toxicity: Degrades readily in the environment via enzymatic and microbial pathways, low impact on terrestrial or aquatic species expected
Persistence and Degradability: Biodegradable, peptides broken down to natural amino acids
Bioaccumulation Potential: Unlikely to bioaccumulate given rapid degradation
Mobility in Soil/Water: Water-soluble, may migrate in moist soils but quickly processed by microbes
Other Adverse Effects: No known long-term ecological risks reported at laboratory use concentrations

Disposal Considerations

Product Disposal: Dispose of unused product and contaminated waste through licensed chemical waste contractor in accordance with local, state, and federal guidelines
Packaging Disposal: Empty vials and syringes should be triple-rinsed and disposed of as laboratory plastic or glass waste per facility SOP
Disposal Restrictions: Do not release bulk peptides directly into environment, avoid landfill disposal of concentrated residues
Contaminated Materials: Dispose of gloves, wipes, or absorbents used in cleanup as hazardous waste if significant spillage occurs

Transport Information

UN Number: Not assigned for non-toxic, non-hazardous peptides
Proper Shipping Name: Laboratory reagent, non-hazardous for transport
Transport Class: Not regulated under ADR, IATA, IMDG, or DOT for laboratory use quantities
Packaging Group: No restrictions, use leak-proof, sealed secondary containers to avoid accidental release
Special Precautions: Avoid temperature extremes during shipping, insulated packaging with dry ice or ice packs recommended for long distances

Regulatory Information

Inventory Status: Exempt from registration under TSCA, REACH, or similar chemical inventories for research-only products
Labeling Requirements: Must carry standard laboratory hazard label stating “for laboratory use only—handle using standard laboratory safety precautions”
SARA/OSHA/WHMIS Status: Not included in hazardous chemical lists for workplace reporting
Other Regulation: Use confined to authorized personnel in research settings, follow institutional biosafety and chemical hygiene plans