Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
QJ5800000
CHEMICAL NAME
:
1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-
CAS REGISTRY
NUMBER :
84-80-0
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR
FORMULA :
C31-H46-O2
MOLECULAR WEIGHT :
450.77
WISWESSER LINE NOTATION :
L66
BV EVJ C1 D2UY1&3Y1&3Y1&3Y1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES
OBSERVED :
Human - man
DOSE/DURATION :
11429 ug/kg/8D-I
TOXIC EFFECTS :
Blood
- eosinophilia Skin and Appendages - dermatitis, other (after systemic
exposure)
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 121,1421,1985
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
>33487 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
GWXXBX German
Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents,
Washington, DC 20231) Volume(issue)/page/year: #2808572
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
25 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 17,1339,1967
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,25,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
>6570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical
Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,653,1982 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4073 No. of
Facilities: 394 (estimated) No. of Industries: 4 No. of Occupations: 23 No. of Employees:
26120 (estimated) No. of Female Employees: 15615 (estimated)
