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vitamin b5
vitamin b5
vitamin b5
vitamin b5
vitamin b5
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Basic
Common Name Calcium pantothenate
CAS Number 137-08-6
Molecular Weight 238.27
Density 1.266g/cm3
Boiling Point 551.5ºC at 760 mmHg
Molecular Formula C9H16NO5.1/2Ca
Melting Point 190 °C
MSDS Chinese USA
Flash Point 145 °C
Physical Chemistry
Density 1.266g/cm3
Boiling Point 551.5ºC at 760 mmHg
Melting Point 190 °C
Molecular Formula C9H16NO5.1/2Ca
Molecular Weight 238.27
Flash Point 145 °C
PSA 191.72000
Index of Refraction 27 ° (C=5, H2O)
Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
RU4375000
CAS REGISTRY NUMBER :
137-08-6
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C18-H32-N2-O10.Ca
MOLECULAR WEIGHT :
476.60
WISWESSER LINE NOTATION :
QV2MVYQX1&1&1Q &-CA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,599,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
820 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,599,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,599,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
920 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
910 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83849 No. of Facilities: 398 (estimated) No. of Industries: 7 No. of Occupations: 22 No. of Employees: 19095 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83849 No. of Facilities: 1870 (estimated) No. of Industries: 10 No. of Occupations: 35 No. of Employees: 29697 (estimated) No. of Female Employees: 7601 (estimated)
Safety
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS RU4375000
HS Code 2936240000
Preparation

N/A

FAQ

1.What is Vitamin B5?

Pantothenic acid Vitamin B5, also called pantothenic acid, is one of 8 B vitamins. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which the body uses to produce energy. These B vitamins, often referred to as B complex vitamins, also help the body use fats and protein. B complex vitamins are needed for healthy skin, hair, eyes, and liver. They also help the nervous system function properly. All B vitamins are water-soluble, meaning that the body does not store them. In addition to playing a role in the breakdown of fats and carbohydrates for energy, vitamin B5 is critical to the manufacture of red blood cells, as well as sex and stress-related hormones produced in the adrenal glands, small glands that sit atop the kidneys. Vitamin B5 is also important in maintaining a healthy digestive tract, and it helps the body use other vitamins, particularly B2 (also called riboflavin). It is sometimes called the "anti-stress" vitamin, but there is no concrete evidence whether it helps the body withstand stress. Your body needs pantothenic acid to synthesize cholesterol. A derivative of pantothenic acid called pantethine is being studied to see if it may help lower cholesterol levels in the body. Vitamin B5 deficiency is rare, but may include symptoms such as fatigue, insomnia, depression, irritability, vomiting, stomach pains, burning feet, and upper respiratory infections.

2.What is the benefit of Vitamin B5?

Vitamin B5 is one of the eight B vitamins. And like other B vitamins, it plays an important role in several processes throughout your body. (Bonus: It also can be a helpful ingredient in your skin care and hair care products.) “B vitamins act as coenzymes, which means they help to either create enzymes our bodies need or activate enzymes that are in your body so they can go and do their jobs,” Romito shares. “Some of those enzymes help with digesting foods and converting foods into energy that our cells can use. Others are used for functions like growing healthy blood cells, replicating DNA or preventing DNA damage.” Here’s what vitamin B5 specifically does for your body. Food metabolism Vitamin B5’s primary goal is to help make and break down fatty acids. That means it helps to turn the fats in the foods you eat into energy. It does that by making a compound in your body called coenzyme A, which helps turn food into energy your body can use to go about its business. In people living with a rare genetic condition called pantothenate kinase-associated neurodegeneration (PKAN), vitamin B5 doesn’t effectively convert into coenzyme A. That can lead to serious and life-threatening loss of function. PKAN is very rare. It’s estimated to affect between 1 and 3 people per million around the world. Improving cholesterol Some early research has suggested that high doses of one form of vitamin B5 may help people with hyperlipidemia (high cholesterol). Some studies have reported that high levels of vitamin B5 can help lower levels of LDL (“bad” cholesterol) and improve or maintain levels of HDL (“good” cholesterol). “It’s still being studied,” Romito says. “But some research has shown that vitamin B5 impacts how lipids are processed and utilized in your body, which can lead to improvements in cholesterol.” In one study of 120 people, researchers showed that participants who took vitamin B5 supplements had small but significant improvements in cholesterol. While the research is promising so far, it’s still preliminary. Future studies will be needed on larger groups of people and following the effects of vitamin B5 on cholesterol for longer periods of time.

3.How much vitamin B5 do you need?

The Food and Nutrition Board at the National Academies of Sciences, Engineering and Medicine set intake recommendations for various nutrients. They recommend the following as adequate intakes of vitamin B5: 6 months and younger: 1.7 milligrams (mg). 7–12 months: 1.8 mg. 1–3 years: 2 mg. 4–8 years: 3 mg. 9–13 years: 4 mg. 14 years and older: 5 mg. People who are pregnant: 6 mg. People who are breastfeeding: 7 mg. There’s no upper limit set for vitamin B5. That means there’s not enough evidence to consider high amounts of vitamin B5 to be a major health risk. But some studies have reported that having more than 10 mg per day of pantothenic acid supplements may be associated with stomach issues, like mild diarrhea.

4.What foods contain vitamin B5?

Certain vitamins tend to be found mostly within certain food groups. When you think of vitamin C, you probably think of citrus and other brightly colored fruits and vegetables. When you think of vitamin K, dark, leafy greens may come to mind. B5 is different in that respect. Because pantothenic acid is found in a wide range of foods and food groups. So, even if you don’t eat meat. Or dairy. Or you’re picky about your veggies. Chances are you’re getting enough B5 from your plate. The National Institutes of Health goes so far as to say, “Almost all plant- and animal-based foods contain pantothenic acid in varying amounts.”

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