Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
QT0525000
CHEMICAL NAME :
Nicotinic
acid
CAS REGISTRY NUMBER :
59-67-6
BEILSTEIN REFERENCE NO. :
0109591
LAST
UPDATED :
199710
DATA ITEMS CITED :
19
MOLECULAR FORMULA
:
C6-H5-N-O2
MOLECULAR WEIGHT :
123.12
WISWESSER LINE NOTATION :
T6NJ
CVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human -
man
DOSE/DURATION :
2571 mg/kg/90D-I
TOXIC EFFECTS :
Blood - change in clotting
factors Blood - changes in platelet count
REFERENCE :
AIMDAP Archives of Internal
Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year:
152,861,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
9713
mg/kg/58W-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Skin and Appendages
- sweating Nutritional and Gross Metabolic - metabolic acidosis
REFERENCE :
SMJOAV
Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1-
1908- Volume(issue)/page/year: 84,496,1991
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical
Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,544,1982
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
730
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box
180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in
Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year:
6,544,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure
threshold
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and
Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 38,241,1938
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
3720 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific
assay) Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri.
Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
Volume(issue)/page/year: 7,149,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
358 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics.
(Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
Volume(issue)/page/year: 14,741,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics.
(Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
Volume(issue)/page/year: 14,741,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8,
Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year:
26,831,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4
gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
BAXXDU British UK Patent Application. (U.S. Patent and Trademark
Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2041937
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4550 mg/kg
TOXIC EFFECTS :
Details
of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo
Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1-
1967- Volume(issue)/page/year: 14,741,1977
TYPE OF TEST :
LDLo - Lowest published
lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or
effect on seizure threshold
REFERENCE :
PSEBAA Proceedings of the Society for
Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1903/04- Volume(issue)/page/year: 38,241,1938 ** TUMORIGENIC DATA **
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
174 gm/kg/94W-C
TOXIC EFFECTS :
Tumorigenic
- Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE
:
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967-
Volume(issue)/page/year: 38,106,1981 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1
mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL
EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code -
81908 No. of Facilities: 1815 (estimated) No. of Industries: 10 No. of Occupations: 19 No.
of Employees: 13494 (estimated) NOES - National Occupational Exposure Survey (1983) NOES
Hazard Code - 81908 No. of Facilities: 3028 (estimated) No. of Industries: 15 No. of
Occupations: 46 No. of Employees: 61057 (estimated) No. of Female Employees: 26152
(estimated)
