Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GG3750000
CHEMICAL NAME :
Cobinamide,
cyanide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D- ribofuranosylbenzimidazole, inner
salt
CAS REGISTRY NUMBER :
68-19-9
LAST UPDATED :
199706
DATA ITEMS CITED
:
11
MOLECULAR FORMULA :
C63-H88-Co-N14-O14-P
MOLECULAR WEIGHT
:
1355.55
WISWESSER LINE NOTATION :
D C5656 B-5 B6 B5 S5 J&5 B-19- Q&6
N&5/B-N/DU/J&-M& J&- O& 9ABBBBCSTT V& AN-CO-&& B-N CN TN C
HEALTH HAZARD DATA
ACUTE
TOXICITY DATA
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE
:
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255,
W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,114,1992
TYPE OF
TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1364
ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL)
V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 49,278,1950
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2727 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
chronic pulmonary edema Blood - other changes
REFERENCE :
ARPAAQ Archives of
Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information,
see APLMAS. Volume(issue)/page/year: 49,278,1950 ** REPRODUCTIVE DATA **
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
115
mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
NATUAS
Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
Volume(issue)/page/year: 242,263,1973
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
168 mg/kg
SEX/DURATION
:
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific
Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental
Abnormalities - urogenital system
REFERENCE :
JPMSAE Journal of Pharmaceutical
Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037)
V.50- 1961- Volume(issue)/page/year: 67,377,1978
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
84
mg/kg
SEX/DURATION :
female 11 day(s) after conception
REFERENCE :
JPMSAE
Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave.,
NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,377,1978 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO COBALT METAL, dust and fume-air:10H TWA 0.05 mg/m3 REFERENCE : NIOSH* National
Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare,
Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL
EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code -
80358 No. of Facilities: 1219 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of
Employees: 19601 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard
Code - 80358 No. of Facilities: 3495 (estimated) No. of Industries: 12 No. of Occupations:
46 No. of Employees: 65178 (estimated) No. of Female Employees: 27980 (estimated)
