Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
VH6750000
CHEMICAL NAME :
Retinol, all
trans-
CAS REGISTRY NUMBER :
68-26-8
BEILSTEIN REFERENCE NO. :
0403040
LAST
UPDATED :
199706
DATA ITEMS CITED :
60
MOLECULAR FORMULA
:
C20-H30-O
MOLECULAR WEIGHT :
286.50
WISWESSER LINE NOTATION :
L6UTJ A1
B1U1Y1&U2U1Y1&U2Q C1 C1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Human - child
DOSE/DURATION :
5475 ku/kg/1Y-I
TOXIC EFFECTS :
Lungs,
Thorax, or Respiration - pleural effusion Gastrointestinal - other changes Musculoskeletal -
other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
1510 mg/kg
TOXIC EFFECTS :
Details
of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
1510 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
73 mL/kg/16D-I
TOXIC EFFECTS :
Musculoskeletal - other
changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -
phosphatases Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
73 mL/kg/16D-I
TOXIC EFFECTS :
Musculoskeletal - other
changes Nutritional and Gross Metabolic - changes in calcium Biochemical - Enzyme
inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
68
mg/kg
SEX/DURATION :
female 1-39 week(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
200
mg/kg
SEX/DURATION :
female 8 week(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo
- Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
76560
ug/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
113 mg/kg
SEX/DURATION :
female
10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental
Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
150 mg/kg
SEX/DURATION :
female 7-10
day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental
Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities -
craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
683 mg/kg
SEX/DURATION :
female 4-16
day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation
mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive -
Fertility - other measures of fertility Reproductive - Effects on Embryo or Fetus - fetal
death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
22 mg/kg
SEX/DURATION :
female 1-22 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation
index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn -
growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
240 mg/kg
SEX/DURATION :
female
9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation
mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive -
Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical
cord)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
1200 ku/kg
SEX/DURATION :
female 6-17 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
craniofacial (including nose and tongue) Reproductive - Effects on Newborn - viability index
(e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn -
behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
60060 ug/kg
SEX/DURATION :
female 10 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
musculoskeletal system Reproductive - Specific Developmental Abnormalities - other
developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE
OF EXPOSURE :
Intraperitoneal
DOSE :
60 mg/kg
SEX/DURATION :
female 10 day(s)
after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
60 mg/kg
SEX/DURATION :
female 10 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
30 mg/kg
SEX/DURATION
:
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific
Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
150
mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and
tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Unreported
DOSE :
72 mg/kg
SEX/DURATION :
female 11-13 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics
(e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
150 mg/kg
SEX/DURATION :
female
9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental
Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities -
other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 mg/kg
SEX/DURATION :
female 3
day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental
Abnormalities - skin and skin appendages
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
120 mg/kg
SEX/DURATION :
female 12
day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental
Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
9610 mg/kg
SEX/DURATION
:
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn -
viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn
- growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 mg/kg
SEX/DURATION
:
lactating female 1 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific
Developmental Abnormalities - skin and skin appendages
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
375 mg/kg
SEX/DURATION
:
female 7-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility -
post-implantation mortality (e.g. dead and/or resorbed implants per total number of
implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
45045 ug/kg
SEX/DURATION :
female 8 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
145 mg/kg
SEX/DURATION :
female 8 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality
(e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility -
litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on
Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo
- Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
145
mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific
Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE
:
145 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific
Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
180
mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific
Developmental Abnormalities - gastrointestinal system
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
96
mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and
tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE
OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Subcutaneous
DOSE :
480 mg/kg
SEX/DURATION :
female 11-14 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal
death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intravenous
DOSE :
12 mg/kg
SEX/DURATION :
female 8 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intramuscular
DOSE :
480 mg/kg
SEX/DURATION :
female 10-13 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities
- musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Intramuscular
DOSE :
120 mg/kg
SEX/DURATION :
female 8 day(s)
after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Intramuscular
DOSE :
240 mg/kg
SEX/DURATION :
female 14-17 day(s)
after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
hepatobiliary system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
DOSE :
45 mg/kg
SEX/DURATION :
female 12 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity
(except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities -
craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities
- musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
DOSE :
77 mg/kg
SEX/DURATION :
female 8-18 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
52550 ug/kg
SEX/DURATION :
female 9-15 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality
(e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
DNA
inhibition
TYPE OF TEST :
DNA inhibition
MUTATION DATA
TYPE OF TEST :
Sister
chromatid exchange
TEST SYSTEM :
Rodent - hamster Cells - not otherwise
specified
DOSE/DURATION :
24 mg/L
REFERENCE :
MUREAV Mutation Research.
(Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
Volume(issue)/page/year: 246,67,1991 *** REVIEWS *** TOXICOLOGY REVIEW CLPTAT Clinical
Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr.,
St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW ARVPAX
Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information,
see ARPTDI. Volume(issue)/page/year: 5,447,1965 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental
Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC
20402) No.1- 1972- Volume(issue)/page/year: 15,121,1976 TOXICOLOGY REVIEW CRTXB2 CRC
Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL
33431) V.1- 1971- Volume(issue)/page/year: 6,351,1979 TOXICOLOGY REIVEW NTIS** National
Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for
Scientific & Technical Information. Volume(issue)/page/year: PB-275-754 TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third
Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year:
6(3),279,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL
EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code
- X1676 No. of Facilities: 546 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of
Employees: 12809 (estimated) No. of Female Employees: 9075 (estimated)
