Common Name	Retinyl acetate
CAS Number	127-47-9
Molecular Weight	328.488
Density	1.0±0.1 g/cm3
Boiling Point	440.5±14.0 °C at 760 mmHg
Molecular Formula	C22H32O2
Melting Point	57-58 °C
MSDS	Chinese USA
Flash Point	124.8±18.5 °C
Symbol	GHS08
Signal Word	Danger

Density	1.0±0.1 g/cm3
Boiling Point	440.5±14.0 °C at 760 mmHg
Melting Point	57-58 °C
Molecular Formula	C22H32O2
Molecular Weight	328.488
Flash Point	124.8±18.5 °C
Exact Mass	328.240234
PSA	26.30000
LogP	7.39
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.532
Storage condition	2-8°C
Water Solubility	soluble

CHEMICAL IDENTIFICATION
RTECS NUMBER :
VH6825000
CHEMICAL NAME :
Retinol, acetate
CAS REGISTRY NUMBER :
127-47-9
BEILSTEIN REFERENCE NO. :
1915439
LAST UPDATED :
199701
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C22-H32-O2
MOLECULAR WEIGHT :
328.54
WISWESSER LINE NOTATION :
L6UTJ A1 B1U1Y1&U2U1Y1&U2OV1 C1 C1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
432 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6352 ku/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6347 mg/kg/21D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Blood - changes in platelet count Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2208 mg/kg/21D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
51800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
95 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
480 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
310 mg/kg
SEX/DURATION :
female 10-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1377 mg/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1377 mg/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
826 mg/kg
SEX/DURATION :
female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1205 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
310 mg/kg
SEX/DURATION :
female 9-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
MUTATION DATA
TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
100 umol/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 44,356,1987 *** REVIEWS *** TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB-275-754 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80572 No. of Facilities: 277 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80572 No. of Facilities: 550 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 13296 (estimated) No. of Female Employees: 7092 (estimated)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360-H413
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R38;R63
Safety Phrases	S36/37-S45
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	VH6825000
HS Code	2936210000

N/A

1.What is Vitamin A Acetate?

Retinyl acetate is a form of vitamin A, a fat-soluble vitamin with many functions in the body. Its different forms are often called “retinoids.” They include retinol, retinal, retinoic acid, and retinyl ester. Retinyl acetate is one type of retinyl ester. While retinyl acetate supplements can be very useful for fixing a deficiency, they can easily cause more harm than good if you already have enough vitamin A. In this article, we will look at retinyl acetate’s main benefits, potential side effects, and how to use it the right way.

2.When is the best time to take retinyl acetate?

Since vitamin A is fat-soluble, you need to take it with a source of fat if you wish to maximize the absorption. More fat will lead to better absorption than less fat in the case of retinyl acetate so you want to take the vitamin or eat the richest sources of it with the meal highest in fat. Whether you take the supplement in the morning or the evening doesn’t really matter. You also do not have to take the vitamin every day. There is not a big difference (if any) between taking 1000 IU every day and taking 3500 IU twice a week.

3.Who will benefit the most?

1.experience symptoms of vitamin A deficiency or you know you are deficient from blood tests 2.don’t get enough vitamin A from food 3.are a vegan or vegetarian 4.are on a low-fat diet 5.have genetics that make you poor at converting carotenoids to retinol (around 50% of us have an impaired 6.ability to convert carotenoids to retinol by 50-75%) 7.supplement with high doses of other fat-soluble vitamins (vitamin D, E, and K) 8.suffer from hypothyroidism, zinc deficiency, or iron deficiency (since these can hurt the conversion of beta-carotene to retinol)

4.Who should not take vitamin A?

1.already get a lot of vitamin A from food 2.do not experience symptoms of deficiency 3.are deficient in other fat-soluble vitamins (D, E, and K) 4.are pregnant (too much vitamin A can cause birth defects, especially in the first 8 weeks of pregnancy) 5.suffer from liver disease (too much vitamin A can make the disease worse)