Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
XI7400000
CHEMICAL NAME :
Thiamine,
nitrate
CAS REGISTRY NUMBER :
532-43-4
LAST UPDATED :
199701
DATA ITEMS CITED
:
9
MOLECULAR FORMULA :
C12-H17-N4-O-S.N-O3
MOLECULAR WEIGHT
:
327.40
WISWESSER LINE NOTATION :
T6N CNJ B1 DZ E1- AT5K CSJ D2Q E1 &Q
&N-O3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
113 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction
or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other
changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and
Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 68,153,1948
TYPE OF TEST :
LD - Lethal dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5
gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year:
42,114,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
387
mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Lungs, Thorax, or
Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
REFERENCE
:
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year:
68,153,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
84
mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Lungs, Thorax, or
Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
REFERENCE
:
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year:
68,153,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
350
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd.,
Tokyo, Japan) Volume(issue)/page/year: 6,449,1982
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical
Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,449,1982 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80545 No. of
Facilities: 177 (estimated) No. of Industries: 4 No. of Occupations: 12 No. of Employees:
15363 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code -
80545 No. of Facilities: 1106 (estimated) No. of Industries: 8 No. of Occupations: 36 No. of
Employees: 39898 (estimated) No. of Female Employees: 18813 (estimated)
