Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
XI7350000
CHEMICAL NAME :
Thiamine,
chloride, hydrochloride
CAS REGISTRY NUMBER :
67-03-8
LAST UPDATED
:
199701
DATA ITEMS CITED :
19
MOLECULAR FORMULA
:
C12-H17-N4-O-S.Cl-H.Cl
MOLECULAR WEIGHT :
337.30
WISWESSER LINE NOTATION
:
T6N CNJ B1 DZ E1- AT5K CSJ D2Q E1 &Q &G &GH
HEALTH HAZARD DATA
ACUTE TOXICITY
DATA
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intramuscular
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
5
mg/kg
TOXIC EFFECTS :
Behavioral - coma Vascular - BP lowering not characterized in
autonomic section Immunological Including Allergic - anaphylaxis
REFERENCE :
AJEMEN
American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
Volume(issue)/page/year: 13,371,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
3710 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis
with or without sensory change Behavioral - tremor Lungs, Thorax, or Respiration - other
changes
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology.
(Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 4,125,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
481 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica.
(Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see
FRMCE8 Volume(issue)/page/year: 24,712,1969
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 6,623,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv
fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For
publisher information, see NSAPCC. Volume(issue)/page/year: 236,149,1959
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
8224 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
IZVIAK Internationale
Zeitschrift fuer Vitaminforschung. International Review of Vitamin Research. (Bern,
Switzerland) V.19-40, 1947-70. For publisher information, see IJVNAP.
Volume(issue)/page/year: 37,82,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
NTIS** National Technical
Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific &
Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent
- mouse
DOSE/DURATION :
74 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica.
(Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see
FRMCE8 Volume(issue)/page/year: 24,712,1969
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal -
cat
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 6,623,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction
or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other
changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and
Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 68,153,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
872 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 6,623,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 6,623,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird -
pigeon
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 6,623,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian -
frog
DOSE/DURATION :
2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 9,1,1959 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
8540 mg/kg/28D-I
TOXIC EFFECTS
:
Related to Chronic Data - death
REFERENCE :
FRPPAO Farmaco, Edizione Pratica.
(Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see
FRMCE8 Volume(issue)/page/year: 24,712,1969
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
11200 mg/kg/28D-I
TOXIC EFFECTS :
Peripheral Nerve and
Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses
(Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure
threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor
Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year:
6,623,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL
EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code -
72200 No. of Facilities: 1288 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of
Employees: 18364 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard
Code - 72200 No. of Facilities: 1872 (estimated) No. of Industries: 10 No. of Occupations:
28 No. of Employees: 48078 (estimated) No. of Female Employees: 31774 (estimated)
