Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
VJ1400000
CHEMICAL NAME
:
Riboflavine
CAS REGISTRY NUMBER :
83-88-5
LAST UPDATED :
199701
DATA
ITEMS CITED :
11
MOLECULAR FORMULA :
C17-H20-N4-O6
MOLECULAR WEIGHT
:
376.41
WISWESSER LINE NOTATION :
T C666 BN DNVMV INJ B1YQYQYQ1Q L1 M1
HEALTH
HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
560
mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Kidney, Ureter, Bladder -
urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight
gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5
gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Mammal - dog
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
MUTATION DATA
TYPE OF TEST
:
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Rodent - hamster
Lung
DOSE/DURATION :
100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier
Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
Volume(issue)/page/year: 373,1,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - 67410 No. of Facilities: 1890 (estimated) No. of Industries: 8 No.
of Occupations: 22 No. of Employees: 24319 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - 67410 No. of Facilities: 2923 (estimated) No. of
Industries: 15 No. of Occupations: 45 No. of Employees: 74790 (estimated) No. of Female
Employees: 35023 (estimated)
