Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UV1350000
CHEMICAL NAME :
Pyridoxol,
hydrochloride
CAS REGISTRY NUMBER :
58-56-0
LAST UPDATED :
199712
DATA ITEMS
CITED :
24
MOLECULAR FORMULA :
C8-H11-N-O3.Cl-H
MOLECULAR WEIGHT
:
205.66
WISWESSER LINE NOTATION :
T6NJ B1 CQ D1Q E1Q &GH
HEALTH HAZARD
DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
4 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3
gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
530
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5500
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2450 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or
effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS
:
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration -
dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>500 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Mammal - cat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral -
convulsions or effect on seizure threshold Gastrointestinal - changes in structure or
function of salivary glands Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Mammal - cat
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Behavioral
- convulsions or effect on seizure threshold Gastrointestinal - changes in structure or
function of salivary glands Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES
OBSERVED :
Mammal - cat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral
- convulsions or effect on seizure threshold Gastrointestinal - changes in structure or
function of salivary glands Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Rodent - rabbit
DOSE/DURATION :
464 mg/kg
TOXIC EFFECTS
:
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird -
pigeon
DOSE/DURATION :
145 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time
(including change in righting reflex) Behavioral - convulsions or effect on seizure
threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
21400
mg/kg/15W-I
TOXIC EFFECTS :
Spinal Cord - demyelination Behavioral - changes in motor
activity (specific assay) Behavioral - ataxia
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 mg/kg
SEX/DURATION :
female
38 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects -
postpartum
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intramuscular
DOSE :
2 mg/kg
SEX/DURATION :
female 38 week(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE
:
8040 ug/kg
SEX/DURATION :
female 14 week(s) pre-mating - 12 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic
TYPE
OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE
:
4 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
15 gm/kg
SEX/DURATION :
male 2 week(s)
pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm
duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
7500 mg/kg
SEX/DURATION :
male 6 week(s)
pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal
vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
15 gm/kg
SEX/DURATION
:
male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects -
spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
MUTATION
DATA
TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human
Lymphocyte
DOSE/DURATION :
2 mg/L
REFERENCE :
MUREAV Mutation Research.
(Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
Volume(issue)/page/year: 124,175,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey
(1983) NOES Hazard Code - X3950 No. of Facilities: 1955 (estimated) No. of Industries: 8 No.
of Occupations: 39 No. of Employees: 57249 (estimated) No. of Female Employees: 35753
(estimated)
