Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
QS3675000
CHEMICAL NAME
:
Nicotinamide
CAS REGISTRY NUMBER :
98-92-0
LAST UPDATED :
199701
DATA
ITEMS CITED :
15
MOLECULAR FORMULA :
C6-H6-N2-O
MOLECULAR WEIGHT
:
122.14
WISWESSER LINE NOTATION :
T6NJ CVZ
HEALTH HAZARD DATA
ACUTE TOXICITY
DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1680
mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species
unspecified
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects
not reported other than lethal dose value
MUTATION DATA
TYPE OF TEST :
Sister
chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
5
mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 126,63,1984 ***
OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS
DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS -
National Occupational Hazard Survey (1974) NOHS Hazard Code - M0321 No. of Facilities: 1142
(estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 17336 (estimated)
NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0321 No. of
Facilities: 2791 (estimated) No. of Industries: 8 No. of Occupations: 34 No. of Employees:
64950 (estimated) No. of Female Employees: 44524 (estimated)
