Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
KH2975000
CHEMICAL NAME :
Ethanaminium,
2-hydroxy-N,N,N-trimethyl-, chloride
CAS REGISTRY NUMBER :
67-48-1
LAST UPDATED
:
199701
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C5-H14-N-O.Cl
MOLECULAR
WEIGHT :
139.65
WISWESSER LINE NOTATION :
Q2K1&1&1 &Q &G
HEALTH HAZARD
DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
3400 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) -
chromodacryorrhea Behavioral - excitement Lungs, Thorax, or Respiration - respiratory
depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
450
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3900 mg/kg
TOXIC
EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or
effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
735
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
53
mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral -
convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory
depression
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
5
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
25
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500
mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration -
other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1
gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1100
ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of
salivary glands
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF
EXPOSURE :
Rectal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1
gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of
salivary glands
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF
EXPOSURE :
Unreported
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION
:
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than
lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
331
mg/kg/14W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased
weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4950
mg/kg/30D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight Endocrine - changes in thymus weight
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
6250 mg/kg/10W-I
TOXIC EFFECTS
:
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
3564 mg/kg/5W-I
TOXIC EFFECTS :
Liver - changes in liver
weight Endocrine - changes in thymus weight Blood - changes in spleen
MUTATION
DATA
TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster
Ovary
DOSE/DURATION :
500 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis.
(New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
Volume(issue)/page/year: 7,1,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.2
mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL
EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code -
19130 No. of Facilities: 198 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of
Employees: 2813 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard
Code - 19130 No. of Facilities: 2227 (estimated) No. of Industries: 10 No. of Occupations:
30 No. of Employees: 31203 (estimated) No. of Female Employees: 8214 (estimated)
