Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
RU4375000
CAS REGISTRY NUMBER
:
137-08-6
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA
:
C18-H32-N2-O10.Ca
MOLECULAR WEIGHT :
476.60
WISWESSER LINE NOTATION
:
QV2MVYQX1&1&1Q &-CA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan
(Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year:
6,599,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
820
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs,
Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society
for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
3400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence
(general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE
:
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year:
45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
830
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd.,
Tokyo, Japan) Volume(issue)/page/year: 6,599,1982
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical
Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,599,1982
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
920
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs,
Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society
for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent
- mouse
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence
(general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE
:
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year:
45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
910
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs,
Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society
for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940 *** NIOSH STANDARDS DEVELOPMENT
AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National
Occupational Hazard Survey (1974) NOHS Hazard Code - 83849 No. of Facilities: 398
(estimated) No. of Industries: 7 No. of Occupations: 22 No. of Employees: 19095 (estimated)
NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83849 No. of
Facilities: 1870 (estimated) No. of Industries: 10 No. of Occupations: 35 No. of Employees:
29697 (estimated) No. of Female Employees: 7601 (estimated)
