Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
XJ9088200
CHEMICAL NAME
:
1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3a-alpha,4-beta,
6a-alpha))-
CAS REGISTRY NUMBER :
58-85-5
LAST UPDATED :
199706
DATA ITEMS
CITED :
7
MOLECULAR FORMULA :
C10-H16-N2-O3-S
MOLECULAR WEIGHT
:
244.34
WISWESSER LINE NOTATION :
T55 BMVM GSTJ H4VQ
HEALTH HAZARD
DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE
OF EXPOSURE :
Subcutaneous
DOSE :
200 mg/kg
SEX/DURATION :
female 14-15
day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus,
cervix, vagina Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g.,
placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except
death, e.g., stunted fetus)
REFERENCE :
JNSVA5 Journal of Nutritional Science and
Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113,
Japan) V.19- 1973- Volume(issue)/page/year: 22,181,1976
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
100
mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive -
Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted
fetus)
REFERENCE :
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar
P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 42,613,1973
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE
:
200 mg/kg
SEX/DURATION :
female 1-2 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed
implants per total number of implants)
REFERENCE :
JNSVA5 Journal of Nutritional
Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku,
Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 21,89,1975
TYPE OF TEST :
TDLo
- Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
17
mg/kg
SEX/DURATION :
female 1-17 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Maternal Effects - other effects
REFERENCE :
EXPEAM Experientia.
(Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
Volume(issue)/page/year: 52,149,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - 80381 No. of Facilities: 129 (estimated) No. of Industries: 2 No.
of Occupations: 8 No. of Employees: 8306 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - 80381 No. of Facilities: 1674 (estimated) No. of
Industries: 9 No. of Occupations: 41 No. of Employees: 46583 (estimated) No. of Female
Employees: 22672 (estimated)
