Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GV7350000
CHEMICAL NAME
:
Cyclohexanesulfamic acid, monosodium salt
CAS REGISTRY NUMBER :
139-05-9
LAST
UPDATED :
199701
DATA ITEMS CITED :
40
MOLECULAR FORMULA
:
C6-H12-N-O3-S.Na
MOLECULAR WEIGHT :
201.24
WISWESSER LINE NOTATION :
L6TJ
AMSWO &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
17 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1154
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4800
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
63 gm/kg/9W-C
TOXIC
EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney
tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
176 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by
RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - tumors at site of
application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
112
gm/kg/8W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter,
Bladder - Kidney tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose
(other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
610 gm/kg/87W-C
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
180
mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
420
gm/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth
statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
168 gm/kg
SEX/DURATION
:
multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation
mortality (e.g. reduction in number of implants per female; total number of implants per
corpora lutea)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects
to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
252 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE
OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Cytogenetic
analysis
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM
:
Rodent - hamster Lung
DOSE/DURATION :
500 mg/L
REFERENCE :
HEREAY Hereditas
(Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947-
Volume(issue)/page/year: 70,271,1972 *** REVIEWS *** IARC Cancer Review:Animal Limited
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Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC
Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year:
22,55,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,178,1987 TOXICOLOGY REVIEW IDJOAS International Dental Journal. (A. Sijthoff, 37 Wagenstr,
The Hague, Netherlands) V.1- 1950- Volume(issue)/page/year: 23,328,1973 TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam,
Netherlands) V.1- 1964- Volume(issue)/page/year: 39,1,1976 TOXICOLOGY REVIEW AEHLAU Archives
of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1-
1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW WMWOA4 Wiener Medizinische
Wochenschrift. (Brueder Hollinek, Gallgasse 40, A-1130 Vienna, Austria) V.1- 1851-
Volume(issue)/page/year: 121,515,1971 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum
Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year:
24,129,1983 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring
St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983 *** NIOSH STANDARDS
DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS -
National Occupational Hazard Survey (1974) NOHS Hazard Code - 83822 No. of Facilities: 21
(estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 83 (estimated) NOES
- National Occupational Exposure Survey (1983) NOES Hazard Code - 83822 No. of Facilities:
294 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 5265
(estimated) No. of Female Employees: 4349 (estimated)
