Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GV7100000
CAS REGISTRY NUMBER
:
139-06-0
LAST UPDATED :
199710
DATA ITEMS CITED :
23
MOLECULAR FORMULA
:
C12-H24-N2-O6-S2.Ca
MOLECULAR WEIGHT :
396.58
WISWESSER LINE NOTATION
:
L6TJ AMSWO 2 &-CA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of
LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and
Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LDLo - Lowest
published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of
New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions,
35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R.
MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St.,
Ottawa, Ont., Canada)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF
EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3500
ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal,
Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont.,
Canada) ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
291 gm/kg/35D-C
TOXIC EFFECTS :
Nutritional and Gross
Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
3465 gm/kg/88W-C
TOXIC EFFECTS
:
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45
gm/kg/66W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS
criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
55 mg/kg
SEX/DURATION
:
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn -
other postnatal measures or effects
TYPE OF TEST :
Sex chromosome loss and
nondisjunction
MUTATION DATA
TEST SYSTEM :
Rodent - gerbil
DOSE/DURATION
:
150 mg/kg
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National
Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada)
V.1- 1959- Volume(issue)/page/year: 13,189,1971 *** REVIEWS *** IARC Cancer Review:Animal
Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC
Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year:
22,55,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,178,1987 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,1,1976 TOXICOLOGY
REVIEW WMWOA4 Wiener Medizinische Wochenschrift. (Brueder Hollinek, Gallgasse 40, A-1130
Vienna, Austria) V.1- 1851- Volume(issue)/page/year: 121,515,1971
