Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UP8225000
CHEMICAL NAME
:
2H-Pyran-2,4(3H)-dione, 3-acetyl-6-methyl-, sodium salt
CAS REGISTRY NUMBER
:
4418-26-2
LAST UPDATED :
199701
DATA ITEMS CITED :
17
MOLECULAR FORMULA
:
C8-H7-O4.Na
MOLECULAR WEIGHT :
190.14
WISWESSER LINE NOTATION :
T6OV DV CHJ
CV1 F1 &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard
Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED
:
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1050 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Mammal - dog
DOSE/DURATION :
452 mg/kg
TOXIC EFFECTS :
Behavioral
- ataxia Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or
function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal -
dog
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate -
monkey
DOSE/DURATION :
6786 mg/kg/26D-I
TOXIC EFFECTS :
Behavioral - convulsions
or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased
weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
female
6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus
- fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental
Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 6-15
day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus -
fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental
Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
female 6-15
day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. #
fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal
death
TYPE OF TEST :
Micronucleus test
MUTATION DATA
TYPE OF TEST
:
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION
:
2500 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub.
Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
*** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology.
(Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued. Volume(issue)/page/year: 4(3),123,1985 *** NIOSH STANDARDS DEVELOPMENT AND
SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational
Exposure Survey (1983) NOES Hazard Code - X2427 No. of Facilities: 130 (estimated) No. of
Industries: 1 No. of Occupations: 1 No. of Employees: 130 (estimated)
