Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UE5950000
CHEMICAL NAME :
Propionic
acid
CAS REGISTRY NUMBER :
79-09-4
BEILSTEIN REFERENCE NO. :
0506071
LAST
UPDATED :
199712
DATA ITEMS CITED :
39
MOLECULAR FORMULA
:
C3-H6-O2
MOLECULAR WEIGHT :
74.09
WISWESSER LINE NOTATION :
QV2
HEALTH
HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Open irritation test
ROUTE OF
EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE
OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the
eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1510 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general
depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
625
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1370
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral
- excitement Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES
OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 uL/kg
TOXIC EFFECTS :
Details
of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo -
Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED
:
Rodent - rabbit
DOSE/DURATION :
1320 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence
(general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration -
dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1640
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14 gm/kg/7D-C
TOXIC
EFFECTS :
Gastrointestinal - other changes
TYPE OF TEST :
TCLo - Lowest published
toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
23 mg/m3/24H/30D-C
TOXIC EFFECTS :
Brain and Coverings -
recordings from specific areas of CNS Blood - changes in erythrocyte (RBC) count Biochemical
- Enzyme inhibition, induction, or change in blood or tissue levels - true
cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4598
mg/kg/9W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin,
cholesterol) Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
33600 mg/kg/7D-C
TOXIC EFFECTS :
Gastrointestinal - other changes
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - hamster
DOSE/DURATION :
42 gm/kg/7D-C
TOXIC EFFECTS
:
Gastrointestinal - other changes
MUTATION DATA
TYPE OF TEST :
Sister chromatid
exchange
TEST SYSTEM :
Human Lymphocyte
REFERENCE :
MUREAV Mutation Research.
(Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
Volume(issue)/page/year: 279,75,1992 *** REVIEWS *** ACGIH TLV-TWA 30 mg/m3 (10 ppm) DTLVS*
The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial
Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
Volume(issue)/page/year: 21,100,1960 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA
10 ppm (30 mg/m3);STEL 15 ppm (45 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (30 mg/m3);STEL 15
ppm (45 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-FRANCE:TWA 10 ppm (30
mg/m3) JAN 1993 OEL-GERMANY:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm
(30 mg/m3) JAN 1993 OEL-RUSSIA:STEL 20 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (30
mg/m3);STEL 20 ppm (60 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3);STEL 15 ppm
(45 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW
ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE
DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PROPIONIC ACID-air:10H TWA 10
ppm;STEL 15 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health,
U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS -
National Occupational Hazard Survey (1974) NOHS Hazard Code - 62460 No. of Facilities: 429
(estimated) No. of Industries: 9 No. of Occupations: 19 No. of Employees: 8081 (estimated)
NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 62460 No. of
Facilities: 1411 (estimated) No. of Industries: 30 No. of Occupations: 42 No. of Employees:
31092 (estimated) No. of Female Employees: 8489 (estimated)
