Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
TK3325000
CHEMICAL NAME
:
Pimaricin
CAS REGISTRY NUMBER :
7681-93-8
LAST UPDATED :
199801
DATA
ITEMS CITED :
27
MOLECULAR FORMULA :
C33-H47-N-O13
MOLECULAR WEIGHT
:
665.81
WISWESSER LINE NOTATION :
T3-25- BO DV SOV IU KU MU OU UUTJ EVQ FQ R1
C&YQ1Q C&Q HO- BT5OTJ CQ DZ EYQ1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
2730 mg/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or
Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
128
mg/kg
TOXIC EFFECTS :
Behavioral - tolerance
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION
:
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than
lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
18
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Mammal - cat
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Mammal - cat
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or
Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal -
cat
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1420 mg/kg
TOXIC
EFFECTS :
Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - rabbit
DOSE/DURATION :
68 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or
Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intramuscular
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
120
mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - guinea pig
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - guinea pig
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Lungs, Thorax,
or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
130
mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST
:
LD30 - Lethal Dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED
:
Mammal - species unspecified
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS
:
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
34104 mg/kg/2Y-C
TOXIC EFFECTS :
Nutritional
and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
7 gm/kg/2W-I
TOXIC EFFECTS :
Gastrointestinal -
hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight
gain Related to Chronic Data - death
MUTATION DATA
TYPE OF TEST :
Sex chromosome
loss and nondisjunction
TEST SYSTEM :
Mold - Aspergillus nidulans
DOSE/DURATION
:
30 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 79,169,1980
