Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UP8050000
CHEMICAL NAME
:
2H-Pyran-2,4(3H)-dione, 3-acetyl-6-methyl-
CAS REGISTRY NUMBER
:
520-45-6
BEILSTEIN REFERENCE NO. :
0006129
LAST UPDATED :
199710
DATA
ITEMS CITED :
14
MOLECULAR FORMULA :
C8-H8-O4
MOLECULAR WEIGHT
:
168.16
WISWESSER LINE NOTATION :
T6OV DV CHJ CV1 F1
HEALTH HAZARD
DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10,
1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- mouse
DOSE/DURATION :
1330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi.
Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1
Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year:
12,520,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1186
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 99,98,1950
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent
- rabbit
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American
College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12,
1982-1993. Discontinued. Volume(issue)/page/year: 4(3),123,1985 ** OTHER MULTIPLE DOSE
TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100
mg/kg/11D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased
weight gain Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology
and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD
21202) V.1- 1909/10- Volume(issue)/page/year: 99,57,1950
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
36400 mg/kg/2Y-C
TOXIC EFFECTS :
Lungs, Thorax, or
Respiration - chronic pulmonary edema Liver - changes in liver weight Nutritional and Gross
Metabolic - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental
Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1-
1909/10- Volume(issue)/page/year: 99,57,1950
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate -
monkey
DOSE/DURATION :
3300 mg/kg/18D-I
TOXIC EFFECTS :
Behavioral - convulsions
or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased
weight gain Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology
and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD
21202) V.1- 1909/10- Volume(issue)/page/year: 99,57,1950 ** TUMORIGENIC DATA **
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
592
mg/kg/37W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS
criteria Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British
Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1-
1947- Volume(issue)/page/year: 20,134,1966 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal
of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York,
NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),123,1985 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1243 No. of
Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1288
(estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1243 No.
of Facilities: 83 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees:
925 (estimated) No. of Female Employees: 679 (estimated)
