Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GD6475000
CHEMICAL NAME
:
Cinnamaldehyde
CAS REGISTRY NUMBER :
104-55-2
BEILSTEIN REFERENCE NO.
:
0605737
LAST UPDATED :
199710
DATA ITEMS CITED :
25
MOLECULAR FORMULA
:
C9-H8-O
MOLECULAR WEIGHT :
132.17
WISWESSER LINE NOTATION
:
VH1U1R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard
Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED
:
Human
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2220 mg/kg
TOXIC
EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal -
hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2225
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1160
mg/kg
TOXIC EFFECTS :
Behavioral - coma
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
35 mg/kg/24W-C
TOXIC EFFECTS :
Liver - changes in liver
weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -
hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Related to Chronic Data
- death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8092
mg/kg/17W-I
TOXIC EFFECTS :
Liver - liver function tests impaired
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
55
mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and
tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
275 mg/kg
SEX/DURATION :
female 7-17 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
musculoskeletal system
TYPE OF TEST :
Sex chromosome loss and
nondisjunction
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM
:
Rodent - hamster Fibroblast
DOSE/DURATION :
15 mg/L
REFERENCE :
FCTOD7 Food
and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY
10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** TOXICOLOGY REVIEW
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115
Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 1(5),5,1981 *** U.S.
STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR
RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83182 No. of
Facilities: 372 (estimated) No. of Industries: 14 No. of Occupations: 38 No. of Employees:
13984 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code -
83182 No. of Facilities: 6159 (estimated) No. of Industries: 58 No. of Occupations: 76 No.
of Employees: 111108 (estimated) No. of Female Employees: 43381 (estimated)
