Common Name	Calcium Propionate
CAS Number	4075-81-4
Molecular Weight	186.219
Density	N/A
Boiling Point	141.7ºC at 760 mmHg
Molecular Formula	C6H10CaO4
Melting Point	300 °C
MSDS	Chinese USA
Flash Point	57.7ºC

Boiling Point	141.7ºC at 760 mmHg
Melting Point	300 °C
Molecular Formula	C6H10CaO4
Molecular Weight	186.219
Flash Point	57.7ºC
Exact Mass	186.020493
PSA	52.60000
LogP	0.80780
Stability	Stable. Hygroscopic. Incompatible with strong oxidizing agents.
Water Solubility	1 g/10 mL

CHEMICAL IDENTIFICATION
RTECS NUMBER :
UE8450000
CHEMICAL NAME :
Propionic acid, calcium salt
CAS REGISTRY NUMBER :
4075-81-4
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C6-H10-O4.Ca
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 27,159,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 27,159,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81755 No. of Facilities: 485 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 2216 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81755 No. of Facilities: 3844 (estimated) No. of Industries: 28 No. of Occupations: 34 No. of Employees: 54706 (estimated) No. of Female Employees: 7852 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UE8450000
HS Code	2915509000

N/A

1.What is Calcium Propionate?

Calcium propionate is the calcium salt of propionic acid. It is a preservative commonly used in baked goods around the world, where it extends their shelf life by inhibiting the growth of spoilage microorganisms, namely mold and ropy bacteria. Characteristics of calcium propionate include: Chemical formula: C6H10O4 Ca Molecular Weight: 186.22 Works best at pH below 5.5 Recommended usage level in bakery: 0.1-0.3% flour weight, but higher levels not uncommon Nutrition: 21 grams of calcium are present in 100 grams of calcium propionate5

2.Is Calcium Propionate Safety?

Calcium propionate has been studied for potential toxicity and for any possibility that it might cause cancer.3 For the most part, the laboratory findings were negative. The accumulation of research evidence indicates that calcium propionate is non-toxic and safe to use in the amounts currently used by food manufacturers. The research was enough for the U.S. Food and Drug Administration's Select Committee on Generally Recognized As Safe (GRAS) Substances to conclude in 1979: "There is no evidence in the available information on propionic acid, calcium propionate, and sodium propionate that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.

3.What Happens When You Eat Calcium Propionate?

Your body doesn't store calcium propionate, so it doesn't build up in any of your cells. When your digestive system is busy breaking down all the foods you eat, it also splits the calcium apart from the propionic acid, which is readily absorbed and metabolized, just like any other fatty acid.5 Then your body eliminates it. There are anecdotal claims that some people are sensitive to calcium propionate and may suffer from migraine headaches triggered by exposure to foods that contain the preservative. But there isn't enough scientific research that backs that claim. That doesn't mean it isn't possible that calcium propionate causes headaches in some people, though. If you think you may have an issue with calcium propionate, it's a good idea to speak with your healthcare provider. They can help you determine what's causing your health problem and talk to you about eating (or avoiding) foods that contain calcium propionate.

4.What is Calcium Propionate used for?

Calcium propionate is used as a preservative in bread and other baked goods, and it may be combined with propionic acid and sodium propionate.1 Calcium propionate helps keep baked goods fresh by preventing mold and bacterial growth that would otherwise cause them to go bad. Calcium propionate also occurs naturally in butter and some types of cheese. Sometimes consumers have questions about the safety of calcium propionate. Many people are concerned about the idea of preservatives that are used as ingredients in the foods we eat. But think of it this way: Do you want to eat bacteria- or mold-infested bread? Probably not. Preservatives such as calcium propionate are important for keeping some healthy foods safe. U.S. Food and Drug Administration. Overview of Food Ingredients, Additives & Colors. Updated February 6, 2018.