Common Name	Calcium acetate
CAS Number	62-54-4
Molecular Weight	158.166
Density	1,5 g/cm3
Boiling Point	117.1ºC at 760 mmHg
Molecular Formula	C4H6CaO4
Melting Point	160°C (dec.)
MSDS	Chinese USA
Flash Point	160°C

Density	1,5 g/cm3
Boiling Point	117.1ºC at 760 mmHg
Melting Point	160°C (dec.)
Molecular Formula	C4H6CaO4
Molecular Weight	158.166
Flash Point	160°C
Exact Mass	157.989197
PSA	52.60000
LogP	0.02760
Water Solubility	soluble

CHEMICAL IDENTIFICATION
RTECS NUMBER :
AF7525000
CHEMICAL NAME :
Acetic acid, calcium salt
CAS REGISTRY NUMBER :
62-54-4
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C4-H6-O4.Ca
MOLECULAR WEIGHT :
158.18
WISWESSER LINE NOTATION :
QV1 &-CA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
147 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
203 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
MUTATION DATA
TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
1290 umol/kg/5D (Intermittent)
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 6,1819,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81751 No. of Facilities: 1286 (estimated) No. of Industries: 29 No. of Occupations: 27 No. of Employees: 10494 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81751 No. of Facilities: 5005 (estimated) No. of Industries: 53 No. of Occupations: 43 No. of Employees: 65011 (estimated) No. of Female Employees: 8166 (estimated)

Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	AF7525000
HS Code	2915299090

N/A

1.What is Calcium Acetate?

Calcium acetate is the calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces. It has a role as a chelator. It contains an acetate. ChEBI The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. DrugBank Calcium Acetate is a calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties. NCI Thesaurus (NCIt)

2.What are the dosages of calcium acetate?

*Capsule/Tablet 667 mg (169 mg elemental Ca) *Oral Solution 667 mg/5 mL (169 mg/5 mL elemental Ca) *Adult: Hyperphosphatemia in End Stage Renal Failure (On Dialysis) Initial: 2 capsules (1334 mg) orally with each meal Increase dose to bring serum phosphate value below 6 mg/dL as long as hypercalcemia does not develop Usual Dose: 3-4 capsules (2001-2868 mg) orally with each meal *Other Information Do not give additional calcium supplements *Pediatric: Safety and efficacy not established *Overdose Overdose of calcium acetate can increase blood calcium levels excessively and lead to hypercalcemia. Symptoms of mild hypercalcemia include nausea, vomiting, loss of appetite and constipation, while severe hypercalcemia can cause confusion, full or partial loss of consciousness and incoherent speech. Treatment of calcium acetate overdose includes discontinuation of calcium acetate and measures to eliminate excess calcium from the blood by increasing excretion in urine, or with hemodialysis in patients with heart failure or kidney insufficiency.

3.What are warnings of calcium acetate?

*Do not use calcium acetate in patients with: 1.High blood calcium levels (hypercalcemia) 2.Hypersensitivity to any of the components in the drug 3.Kidney stones *Calcium acetate can cause gas, bloating and constipation. *Use with caution in patients who are at risk for irregular heart rhythms or those taking digitalis, calcium acetate may precipitate arrhythmia. *Treatment with calcium acetate can cause hypercalcemia in patients with end-stage renal disease. Avoid concurrent use of calcium supplements. *Monitor calcium levels twice weekly, in the early phase of treatment and when adjusting dosage, because overdosing may lead to progressive hypercalcemia. If the patient develops hypercalcemia, reduce dosage or discontinue calcium acetate, depending on the severity. In addition, decrease or discontinue any concomitant vitamin D therapy. *Chronic hypercalcemia can lead to calcification of soft tissue and blood vessels. *Advise patients to reduce intake of oxalate-rich foods to avoid calcium-oxalate formation. *Calcium administration interferes with the absorption of some minerals and drugs, use with caution. *Oral solution contains maltitol, a sugar substitute, which may have a laxative effect. *Some formulations may contain propylene glycol which can be toxic in large amounts.

4.What is Silicon Dioxide used for?

Calcium acetate is a medication used to reduce blood phosphate levels (hyperphosphatemia), a complication associated with advanced kidney disease. Patients with end-stage renal disease are prone to phosphate retention, which causes secondary hyperparathyroidism, leading to renal osteodystrophy, a bone disease, and calcification of soft tissue. Treatment for hyperphosphatemia includes a reduction in dietary intake of phosphate and removal of phosphate with efficient dialysis methods. In addition, calcium acetate is used to eliminate any phosphate absorbed from food. When taken with meals, calcium acetate binds to dietary phosphate to form insoluble calcium phosphate that cannot be absorbed by the body, which is then excreted in the stools.