Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
AG6825000
CHEMICAL NAME :
Acetic acid,
(2,4-dichlorophenoxy)-
CAS REGISTRY NUMBER :
94-75-7
BEILSTEIN REFERENCE NO.
:
1214242
LAST UPDATED :
199806
DATA ITEMS CITED :
122
MOLECULAR FORMULA
:
C8-H6-Cl2-O3
MOLECULAR WEIGHT :
221.04
WISWESSER LINE NOTATION :
QV1OR BG
DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize
test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent
- rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration
into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human -
man
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or
Respiration - respiratory depression
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION
:
5714 mg/kg
TOXIC EFFECTS :
Behavioral - coma Cardiac - change in rate Lungs,
Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LDLo - Lowest published
lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION
:
80 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Behavioral - coma
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LDLo - Lowest
published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human -
man
DOSE/DURATION :
93 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect
on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
375
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than
lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
666 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with
or without sensory change Behavioral - muscle weakness Behavioral - coma
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
347 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest
published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal -
dog
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - stiffness Behavioral
- coma
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
800 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto
the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1400 mg/kg
TOXIC
EFFECTS :
Behavioral - ataxia Skin and Appendages - primary irritation (after topical
exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
400
mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or
without sensory change Behavioral - muscle weakness Behavioral - coma
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Rodent - rabbit
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS
:
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
Behavioral - muscle weakness Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
469 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
666 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation -
spastic paralysis with or without sensory change Behavioral - muscle weakness Behavioral -
coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
500 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Bird - chicken
DOSE/DURATION :
541 mg/kg
TOXIC EFFECTS
:
Gastrointestinal - gastritis Behavioral - somnolence (general depressed activity) Liver
- fatty liver degeneration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE
OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION
:
375 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
54600
mg/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in
thyroid weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13650
mg/kg/13W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased
weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200
mg/kg/5W-I
TOXIC EFFECTS :
Behavioral - muscle weakness
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
54750 mg/kg/1Y-C
TOXIC EFFECTS :
Sense Organs and Special
Senses (Eye) - retinal changes (pigmentary depositions, retinitis, other) Behavioral -
changes in motor activity (specific assay)
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
91 gm/kg/2Y-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder -
changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter,
Bladder - changes in bladder weight
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION
:
700 mg/kg/90D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic
Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1820
mg/kg/52W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including
acute renal failure, acute tubular necrosis) Liver - other changes Blood - changes in serum
composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal -
dog
DOSE/DURATION :
300 mg/kg/6D-I
TOXIC EFFECTS :
Musculoskeletal - changes in
teeth and supporting structures Skin and Appendages - dermatitis, other (after systemic
exposure) Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
220 ug/kg
SEX/DURATION :
female 1-22
day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental
Abnormalities - blood and lymphatic systems (including spleen and marrow)
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1
gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
125 mg/kg
SEX/DURATION
:
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific
Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION
:
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on
Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific
Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental
Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 6-15
day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental
Abnormalities - homeostasis Reproductive - Effects on Newborn - growth statistics (e.g.%,
reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Intraperitoneal
DOSE :
1600 mg/kg
SEX/DURATION :
female 9-25
day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth
statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and
metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
600 mg/kg
SEX/DURATION :
female 9-15 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics
(e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and
metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
1 gm/kg
SEX/DURATION :
female 15-24 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and
metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
707 mg/kg
SEX/DURATION :
female 11-14 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity
(except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and
tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
900 mg/kg
SEX/DURATION :
female 6-14 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per
litter; measured before birth) Reproductive - Effects on Embryo or Fetus - extra-embryonic
structures (e.g., placenta, umbilical cord) Reproductive - Specific Developmental
Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
DOSE :
438 mg/kg
SEX/DURATION :
female 8-12 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics
(e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
882 mg/kg
SEX/DURATION
:
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on
Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central
Nervous System Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g.,
placenta, umbilical cord)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE
OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 6-14 day(s)
after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus -
fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental
Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE
OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 6-14 day(s)
after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality
(e.g. reduction in number of implants per female; total number of implants per corpora
lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before
birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
200 mg/kg
SEX/DURATION :
female 7-11 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per
litter; measured before birth)
TYPE OF TEST :
Specific locus test
TYPE OF TEST
:
Specific locus test
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE
OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Cytogenetic
analysis
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Cytogenetic
analysis
MUTATION DATA
TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal -
species unspecified Lymphocyte
REFERENCE :
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Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA
10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs)
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*** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal
Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1-
1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 10 mg/m3 DTLVS* The
Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year: 3,67,1971 OSHA PEL (Gen Indu):8H TWA 10 mg/m3 CFRGBR Code of
Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC
20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 10 mg/m3 CFRGBR
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10
mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed
Cont):8H TWA 10 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 ***
OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993 OEL-AUSTRIA:TWA 10
mg/m3 JAN 1993 OEL-BELGIUM:TWA 10 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993
OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 10 mg/m3 JAN 1993
AOEL-GERMANY:TWA 10 mg/m3 JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 10 mg/m3 JAN 1993
OEL-POLAND:TWA 7 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 mg/m3;STEL 50 mg/m3 JAN 1993
OEL-THAILAND:TWA 10 mg/m3 JAN 1993 OEL-TURKEY:TWA 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA
10 mg/m3;STEL 20 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL
IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND
SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2,4-D-air:10H
TWA 10 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S.
Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year:
DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational
Hazard Survey (1974) NOHS Hazard Code - 24270 No. of Facilities: 1132 (estimated) No. of
Industries: 6 No. of Occupations: 8 No. of Employees: 6266 (estimated) NOES - National
Occupational Exposure Survey (1983) NOES Hazard Code - 24270 No. of Facilities: 94
(estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 471 (estimated)
