Common Name	Curcumin
CAS Number	458-37-7
Molecular Weight	368.380
Density	1.3±0.1 g/cm3
Boiling Point	593.2±50.0 °C at 760 mmHg
Molecular Formula	C21H20O6
Melting Point	183 °C
MSDS	Chinese USA
Flash Point	209.7±23.6 °C
Symbol	GHS07
Signal Word	Warning

Density	1.3±0.1 g/cm3
Boiling Point	593.2±50.0 °C at 760 mmHg
Melting Point	183 °C
Molecular Formula	C21H20O6
Molecular Weight	368.380
Flash Point	209.7±23.6 °C
Exact Mass	368.125977
PSA	96.22000
LogP	2.85
Vapour density	13 (vs air)
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.672
Storage condition	−20°C
Water Solubility	Slightly soluble (hot)

CHEMICAL IDENTIFICATION
RTECS NUMBER :
MI5230000
CHEMICAL NAME :
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
CAS REGISTRY NUMBER :
458-37-7
BEILSTEIN REFERENCE NO. :
2306965
LAST UPDATED :
199801
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C21-H20-O6
MOLECULAR WEIGHT :
368.41
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
20 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4425 No. of Facilities: 145 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 690 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	MI5230000
HS Code	2932999099

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1.What is Curcumin?

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). Turmeric's other two curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin. The curcuminoids are natural phenols that are responsible for the yellow color of turmeric. Curcumin can exist in several tautomeric forms, including a 1,3-diketo form and two equivalent enol forms. The enol form is more energetically stable in the solid phase and in solution.Curcumin can be used for boron quantification in the curcumin method. It reacts with boric acid to form a red-colored compound, rosocyanine.Curcumin is brightly yellow colored and may be used as a food coloring.

2.How is Curcumin produced?

1) Resin separation technology. Resin technology has long been successfully applied to industrial decolorization, environmental protection, drug analysis, antibiotic extraction and separation and other fields. Used in the separation and concentration of phytochemical components has also been a great success. For example, for ginkgo biloba, the current resin separation technology can achieve a collection rate of 90% of ginkgo flavonoids; can be a one-time concentration of ginkgo flavonoids, so that the content of more than 50%; can also remove the vast majority (more than 99.5%) as a harmful ingredient of ginkgolides, so that it is less than 5 ppm, and at the same time to make the active ingredient loss of control in the following 3%. (2) Industrial extraction technology.

3.How is Curcumin stored and distributed?

Store under dry inert gas, keep container tightly closed, store in a cool, dry place Packed in galvanized iron drums. Store in a cool, ventilated place. The storage should be dedicated and not mixed with other items. Pay attention to fire prevention. Polymerization inhibitor should be added before storage and transportation. Before transportation, check whether the packing container is complete and sealed, and make sure the container is not leaking, collapsing, falling or damaged during transportation. Strictly prohibit mixing and transporting with oxidizing agents, acids, alkalis, edible chemicals and so on. The transport vehicle and ship must be thoroughly cleaned and sterilized, otherwise it is not allowed to ship other items. When transported by ship, the fitting position should be far away from bedrooms, kitchens, and isolated from the cabin, power supply, fire source and other parts. Road transportation should follow the prescribed route.

4.What is Curcumin used for?

Application Scenarios of Plant Extracts Plant extracts are varied and functional, and one kind of extracts often has different roles, but they can be roughly divided into five categories: coloring, flavor output, pharmacological effects and health care functions. Coloring: Phytochrome is the main component of plants presenting color, and some plants are unusually rich in pigment content, which can be used for pigment extraction. There are dozens of available phytochromes in our country, such as curcumin, safflower yellow, radish red, beet red, sorghum red, and paprika red. Flavor output: Plant extracts are often rich in characteristic components that effectively stimulate the senses, such as sweeteners and volatiles. Natural sweeteners are now popular new sweeteners that not only have outstanding sweetness, but are also ideal alternatives to cane sugar.