Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UX7350000
CHEMICAL NAME :
Pyrophosphoric
acid, tetrasodium salt
CAS REGISTRY NUMBER :
7722-88-5
LAST UPDATED
:
199712
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
O7-P2.4Na
MOLECULAR
WEIGHT :
265.90
WISWESSER LINE NOTATION :
NA4 P2-O7
HEALTH HAZARD DATA
ACUTE
TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE
:
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255,
W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,172,1957
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
59
mg/kg
TOXIC EFFECTS :
Behavioral - excitement Nutritional and Gross Metabolic - weight
loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and
Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
V.1- 1909/10- Volume(issue)/page/year: 108,117,1953
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 7,172,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
2980 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than
lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio
Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 7,445,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 7,445,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
69 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug
Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 7,445,1957
TYPE OF TEST :
LD - Lethal dose
ROUTE OF
EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
>300 mg/kg
REFERENCE :
ATDAEI Acute Toxicity Data.
Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third
Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,47,1990 *** REVIEWS ***
ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure
Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists
(ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW ARZNAD
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,24,1957 *** U.S. STANDARDS
AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington,
DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS
*** OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg/m3 JAN 1993 OEL-DENMARK:TWA 5
mg/m3 JAN 1993 OEL-FINLAND:TWA 5 mg/m3 JAN 1993 OEL-FRANCE:TWA 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993 OEL IN
BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM
check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED
EXPOSURE LEVEL (REL) : NIOSH REL TO TETRASODIUM PYROPHOSPHATE-air:10H TWA 5 mg/m3 REFERENCE
: NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health,
Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80224 No. of Facilities: 22297 (estimated) No. of Industries: 179 No. of
Occupations: 108 No. of Employees: 177064 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - 80224 No. of Facilities: 31059 (estimated) No. of
Industries: 223 No. of Occupations: 144 No. of Employees: 566370 (estimated) No. of Female
Employees: 244801 (estimated)
