Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
YK4570000
CHEMICAL NAME :
Triphosphoric
acid, pentasodium salt
CAS REGISTRY NUMBER :
7758-29-4
LAST UPDATED
:
199712
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
O10-P3.5Na
MOLECULAR
WEIGHT :
367.86
WISWESSER LINE NOTATION :
NA5 P3-O5
HEALTH HAZARD DATA
ACUTE
TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3120 mg/kg
TOXIC
EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral -
coma
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA
22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0545589
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
525 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE
:
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co.,
428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year:
108,117,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2060
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
VLUBB6 Vestnik Leningradskogo Universiteta, Biologiya. Journal of
Leningrad University, Biology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1956-
Volume(issue)/page/year: (3),97,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
3100 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis
without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general
depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE
:
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya
Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(9),19,1973
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
700
mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute
renal failure, acute tubular necrosis)
REFERENCE :
REPMBN Revue d'Epidemiologie,
Medecine Sociale et Sante Publique. (Masson Editeur, 120 Blvd. Saint-Germain, F-75280 Paris
Cedex O6, France) V.1- 1953- Volume(issue)/page/year: 10,391,1962
TYPE OF TEST :
LD50
- Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
ARZNAD
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES
OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS
:
Details of toxic effects not reported other than lethal dose value
REFERENCE
:
VLUBB6 Vestnik Leningradskogo Universiteta, Biologiya. Journal of Leningrad University,
Biology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1956-
Volume(issue)/page/year: (3),97,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
2730 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine -
changes in spleen weight
REFERENCE :
GISAAA Gigiena i Sanitariya. For English
translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 38(9),19,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - 80076 No. of Facilities: 101624 (estimated) No. of Industries: 308
No. of Occupations: 153 No. of Employees: 930493 (estimated) NOES - National Occupational
Exposure Survey (1983) NOES Hazard Code - 80076 No. of Facilities: 49146 (estimated) No. of
Industries: 268 No. of Occupations: 169 No. of Employees: 943961 (estimated) No. of Female
Employees: 347961 (estimated)
