Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
ZH4810000
CHEMICAL NAME :
Zinc
oxide
CAS REGISTRY NUMBER :
1314-13-2
LAST UPDATED :
199806
DATA ITEMS CITED
:
70
MOLECULAR FORMULA :
O-Zn
MOLECULAR WEIGHT :
81.37
WISWESSER LINE
NOTATION :
ZN O
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES
OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST
:
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Human
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects
not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic
concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED
:
Human
DOSE/DURATION :
600 mg/m3
TOXIC EFFECTS :
Lungs, Thorax, or
Respiration - cough Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration -
other changes
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>8437 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
240
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7950 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
:
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500
mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17431
mg/kg/90D-C
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific
assay)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
:
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5900
ug/m3/3H/3D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -
phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels
- dehydrogenases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE
OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION
:
4600 ug/m3/3H/6D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Lungs, Thorax, or Respiration - changes in lung weight
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird -
chicken
DOSE/DURATION :
32203 mg/kg/4W-C
TOXIC EFFECTS :
Endocrine - changes in
growth hormone Endocrine - evidence of thyroid hypofunction Nutritional and Gross Metabolic
- weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal -
domestic
DOSE/DURATION :
3584 mg/kg/4W-I
TOXIC EFFECTS :
Gastrointestinal -
changes in structure or function of endocrine pancreas Blood - changes in serum composition
(e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not
otherwise specified
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
DOSE :
6846 mg/kg
SEX/DURATION :
female 1-22 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
homeostasis Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn
- growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
Cytogenetic
analysis
MUTATION DATA
TEST SYSTEM :
Rodent - guinea pig
REFERENCE :
TXAPA9
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1959- Volume(issue)/page/year: 78,29,1985 *** REVIEWS *** ACGIH TLV-STEL 10
mg/m3, fume DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs)
booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH),
Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 5 mg/m3, fume
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet
issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH,
1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3, inhalable dust DTLVS* The
Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW ANAEA3 Annals of Allergy. (American
College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year:
35,165,1975 TOXICOLOGY REVIEW JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17,
1919-35. For publisher information, see AEHLAU. Volume(issue)/page/year: 8,322,1926 *** U.S.
STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR
RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA
STANDARD-air:TWA 5 mg/m3 (fume) DTLVS* The Threshold Limit Values (TLVs) and Biological
Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,284,1971 OSHA PEL (Gen
Indu):8H TWA 5 mg/m3, fume and respirable fraction CFRGBR Code of Federal Regulations. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402)
Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA
5 mg/m3, fume and respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government
Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994 OSHA PEL (Construc):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal
Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 mg/m3, fume and
respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA
PEL (Shipyard):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402)
Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 mg/m3 CFRGBR Code of
Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC
20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 5 mg/m3 JAN 1993 OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-AUSTRALIA:TWA 5 mg/m3;STEL 10 mg/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg/m3;STEL 10 mg/m3 (fume) JAN 1993 OEL-DENMARK:TWA 4 mg/m3 (fume) JAN
1993 OEL-DENMARK:TWA 4 mg/m3 (dust) JAN 1993 OEL-FINLAND:TWA 5 mg/m3 (fume) JAN 1993
OEL-FRANCE:TWA 10 mg/m3 JAN 1993 OEL-FRANCE:TWA 5 mg/m3 (fume) JAN 1993 OEL-GERMANY:TWA 5
mg/m3 (fume) JAN 1993 OEL-HUNGARY:TWA 5 mg/m3 JAN 1993 OEL-JAPAN:TWA 5 mg/m3 (fume) JAN 1993
OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 1 mg/m3 JAN 1993
OEL-POLAND:TWA 5 mg/m3 (fume) JAN 1993 OEL-SWEDEN:TWA 5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5
mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3 (fume) JAN 1993 OEL-THAILAND:TWA 5 mg/m3 (fume)
JAN 1993 OEL-TURKEY:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 JAN
1993 OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 (fume) JAN 1993 OEL IN BULGARIA, COLOMBIA,
JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV ***
NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL)
: NIOSH REL TO ZINC OXIDE, fume-air:10H TWA 5 mg/m3;STEL 10 mg/m3 REFERENCE : NIOSH*
National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH RECOMMENDED
EXPOSURE LEVEL (REL) : NIOSH REL TO ZINC OXIDE, total dust-air:TWA 5 mg/m3;CL 15 mg/m3/15M
REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS
#92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - X5686 No. of Facilities: 56635 (estimated) No. of
Industries: 295 No. of Occupations: 168 No. of Employees: 919197 (estimated) No. of Female
Employees: 151582 (estimated) NOES - National Occupational Exposure Survey (1983) NOES
Hazard Code - X9509 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of
Occupations: 1 No. of Employees: 105 (estimated) No. of Female Employees: 7 (estimated)
