| Common Name | Synephrine hydrochloride |
| CAS Number | 5985-28-4 |
| Molecular Weight | 203.666 |
| Density | N/A |
| Boiling Point | 341.1ºC at 760 mmHg |
| Molecular Formula | C9H14ClNO2 |
| Melting Point | 147-150ºC |
| MSDS | N/A |
| Flash Point | 163.4ºC |
| Boiling Point | 341.1ºC at 760 mmHg |
| Melting Point | 147-150ºC |
| Molecular Formula | C9H14ClNO2 |
| Molecular Weight | 203.666 |
| Flash Point | 163.4ºC |
| Exact Mass | 203.071304 |
| PSA | 52.49000 |
| LogP | 1.83790 |
| Storage condition | Refrigerator |
| Hazard Codes | Xi |
| HS Code | 2922199090 |
N/A
1.What is Ferrous Gluconate?
Synephrine HCL is a naturally occurring alkaloid chemical compound found plants and extracted for use as a supplement. Bitter orange is the most popular synephrine plant and has a history of its own. The use of bitter orange in the Americas dates back to the 1500’s, but has roots in China and groups indigenous to the Amazon jungle. These Chinese used bitter orange, usually in a tonic, to help with gastrointestinal issues like nausea, indigestion and constipation, while it was traditionally used in Brazil as anticonvulsant and to help with anxiety and sleeplessness. The vast differences in how these two cultures on different sides of the planet make it easy to understand why some see bitter orange as a magical supplement. Bitter orange is currently used for a number similar issues as well as some more modern-day troubles like weight loss and as an aid in the battle against athlete’s foot. Synephrine is one of the main compounds in bitter orange and thought to be the foundation of the plant’s healing qualities. Synephrine’s molecular structure is similar to ephedrine, arguably the most effective fat burning ingredients. Ephedrine can no longer be sold as a dietary supplement (and neither can methylsynephrine), which is why synephrine is the next best substitute. Synephrine’s metabolite is octopamine, which is another supplement promoted for its fat burning potential.
2.What are uses of Synephrine HCL?
While bitter orange has a vast scope of potential uses, synephrine has been primarily used and studied for its effects on weight and fat loss. It does have some other interesting uses as well and, if differences in bitter orange use are any indicator, the uses will continue to span multiple areas over time. Weight Loss. Synephrine is often compared to ephedrine, the banned stimulant that was once the basis of many weight loss supplements. In fact, when ephedrine was banned, many supplement manufacturers replaced ephidrine with synephrine. Clinical studies have backed up synephrine’s positive impact on fat burning and weight loss. Synephrine helps increase the body’s metabolic rate and increases lypolysis (fat breakdown). It also functions as an alpha-androgenic antagonist. Synephrine works with receptors located in fat tissue that help enhance the lypolysis within that tissue and with receptors that increase thermogenesis of muscle, which also results in weight loss. Appetite Supressant. Synephrine’s stimulant properties make it an effective appetite suppressant. Reducing caloric intake is the key to rapid fat loss. Using an appetite supressant can help you curb cravings and make it easier to eat healthy. Muscle uptake of glucose. Synephrine can stimulate glucose uptake by skeletal muscle. This function has potential in a couple areas. First, it helps you lose fat by removing excess glucose from the bloodstream and second, it provides muscles with glucose that can be used efficiently for energy. More intramuscular glucose could lead to greater muscle volume and strength.
3.How much synephrine should I take?
A typical dose of 4-20 mg of synephrine daily can be found suggested by products providing the standardized citrus aurantium extract of 200-600mg per pill. These contain about 3-6% of synephrine. Of course, you should always follow the label directions found on the package of the supplement.
4.What are Side Effects & Precautions?
Reported side effects of synephrine-containing supplements include: Hallucinations/psychosis Coronary spasms and thrombosis Heart rhythm disturbances (ventricular fibrillation) A decrease in muscle size (rhabdomyolysis) Kidney failure Blood clots Nerve damage due to increased pressure in muscles (bilateral compartment syndrome) Chest pain (variant angina) Stroke A review of 30 human studies involving over 600 subjects concluded that p‐synephrine (within a bitter orange extract) did not adversely affect the heart, liver, kidneys, or thyroid at doses of up to 100 mg. Over 40% of these subjects consumed caffeine in conjunction with bitter orange extract (which contains p‐synephrine) . Higher doses of synephrine have also produced worse adverse effects in safety studies. A study of mice showed high rates of serious side effects, including gasping and reduced motor function. The study used very high doses of synephrine: 150 to 2,000 mg/kg of body mass, compared to the recommended dose of 2 mg/kg body mass or less . Caffeine combined with synephrine may be more likely to cause elevated blood pressure and heart rate than synephrine alone, with the risk being even greater when high doses of caffeine were taken (320 mg daily or more) Further, in studies in mice both bitter orange (C. aurantium) extract and caffeine increase blood pressure, while pure synephrine had minimal effects on heart rate and blood pressure. If you take synephrine and experience cardiac symptoms, seek medical attention immediately. Your doctor can determine whether medical intervention is necessary.
