Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
LZ5230000
CHEMICAL NAME :
Gluconic acid,
monopotassium salt, D-
CAS REGISTRY NUMBER :
299-27-4
LAST UPDATED
:
199701
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C6-H11-O7.K
MOLECULAR
WEIGHT :
234.27
WISWESSER LINE NOTATION :
Q1YQYQYQYQVO &-KA-
HEALTH HAZARD
DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
10380 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect,
not otherwise specified Behavioral - sleep Behavioral - altered sleep time (including change
in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co.,
Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,810,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
2664 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical
Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)
V.1- 1960- Volume(issue)/page/year: 6,810,1972
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
9650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical
Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)
V.1- 1960- Volume(issue)/page/year: 6,810,1972
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
9100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses
(Olfaction) - effect, not otherwise specified Behavioral - sleep Behavioral - altered sleep
time (including change in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical
Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)
V.1- 1960- Volume(issue)/page/year: 6,810,1972
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical
Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)
V.1- 1960- Volume(issue)/page/year: 6,810,1972
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
8190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical
Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)
V.1- 1960- Volume(issue)/page/year: 6,810,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA
**
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
358
gm/kg/32D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in potassium
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -
transaminases Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho.
Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101,
Japan) V.1- 1960- Volume(issue)/page/year: 6,998,1972
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1456 gm/kg/26W-I
TOXIC EFFECTS :
Behavioral - food intake
(animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to
Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha
Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,1043,1972
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
358 gm/kg/32D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules
(including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in
bladder weight Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho.
Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101,
Japan) V.1- 1960- Volume(issue)/page/year: 6,998,1972
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
1456 gm/kg/26W-I
TOXIC EFFECTS :
Behavioral - food intake
(animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to
Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha
Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 6,1043,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - 80489 No. of Facilities: 2945 (estimated) No. of Industries: 4 No.
of Occupations: 14 No. of Employees: 17170 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - 80489 No. of Facilities: 234 (estimated) No. of Industries:
4 No. of Occupations: 14 No. of Employees: 7786 (estimated) No. of Female Employees: 2416
(estimated)
