Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
OP1050000
CAS REGISTRY NUMBER
:
7785-87-7
LAST UPDATED :
199712
DATA ITEMS CITED :
41
MOLECULAR FORMULA
:
O4-S.Mn
MOLECULAR WEIGHT :
151.00
WISWESSER LINE NOTATION
:
.MN..S-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
2150 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence
(general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
92600
ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral
- convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
44100 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general
depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
2330 mg/kg
TOXIC EFFECTS :
Behavioral -
somnolence (general depressed activity) Behavioral - convulsions or effect on seizure
threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
147
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral
- convulsions or effect on seizure threshold
TYPE OF TEST :
LD - Lethal dose
ROUTE
OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
>31600 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
660 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic -
neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15
gm/kg
SEX/DURATION :
female 6 week(s) pre-mating female 1-3 week(s) after conception
lactating female 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Fertility -
post-implantation mortality (e.g. dead and/or resorbed implants per total number of
implants) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
34356
ug/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed
implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
68711 ug/kg
SEX/DURATION
:
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific
Developmental Abnormalities - Central Nervous System
MUTATION DATA
TYPE OF TEST
:
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Yeast - Saccharomyces
cerevisiae
DOSE/DURATION :
3 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford
Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
Volume(issue)/page/year: 1,21,1986 *** REVIEWS *** ACGIH TLV-TWA 0.2 mg(Mn)/m3 DTLVS* The
Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects
of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Mn,121,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA
STANDARD-air:CL 5 mg(Mn)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure
Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists
(ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,149,1971 OSHA PEL (Gen Indu):CL 5
mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL
(Construc):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government
Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993 OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN 1993 OEL-DENMARK:TWA
2.5 mg(Mn)/m3 JAN 1993 OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993 OEL-HUNGARY:TWA 0.3
mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993 OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN 1993 OEL-THE
NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(Mn)/m3 JAN 1993 OEL-SWEDEN:TWA 1
mg(Mn)/m3;STEL 2.5 mg(Mn)/m3 (resp. dust) JAN 1993 OEL-SWEDEN:TWA 2.5 mg(Mn)/m3;STEL 5
mg(Mn)/m3 (total dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993 OEL IN BULGARIA,
COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH
TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE
SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81680 No.
of Facilities: 970 (estimated) No. of Industries: 25 No. of Occupations: 22 No. of
Employees: 14580 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard
Code - 81680 No. of Facilities: 1307 (estimated) No. of Industries: 20 No. of Occupations:
43 No. of Employees: 35426 (estimated) No. of Female Employees: 15477 (estimated)
