Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
OO9625000
CAS REGISTRY NUMBER
:
7773-01-5
LAST UPDATED :
199806
DATA ITEMS CITED :
86
MOLECULAR FORMULA
:
Cl2-Mn
MOLECULAR WEIGHT :
125.84
WISWESSER LINE NOTATION :
MN G2
HEALTH
HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
147
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral
- convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
92600 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general
depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
1031 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral
- convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other
changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
121
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
210
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral
- ataxia Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
255 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal -
dog
DOSE/DURATION :
202 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal -
dog
DOSE/DURATION :
128 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Vascular -
BP lowering not characterized in autonomic section Gastrointestinal - other changes
TYPE
OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Unreported
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
600
ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Unreported
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
4 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
180
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
64800
ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
41
mg/kg
TOXIC EFFECTS :
Cardiac - other changes Vascular - BP lowering not characterized
in autonomic section Gastrointestinal - other changes
TYPE OF TEST :
LDLo - Lowest
published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
6500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
916 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral -
convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other
changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
180
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
60
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1240
mg/kg/7D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Effect on specific coenzyme - not otherwise specified Biochemical -
Neurotransmitters or modulators (putative) - dopamine in striatum
TYPE OF TEST :
TDLo
- Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
2520 mg/kg/3W-C
TOXIC EFFECTS :
Brain and Coverings -
other degenerative changes Vascular - BP lowering not characterized in autonomic section
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other
Enzymes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2405
mg/kg/30D-C
TOXIC EFFECTS :
Liver - other changes Blood - changes in serum composition
(e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in
blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
245 gm/kg/35W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - changes in metals, not otherwise specified Biochemical -
Enzyme inhibition, induction, or change in blood or tissue levels - other
oxidoreductases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
630
mg/kg/6W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Blood -
changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism
(Intermediary) - other
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
271
gm/kg/1Y-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg/4W-I
TOXIC EFFECTS
:
Liver - changes in liver weight Endocrine - changes in spleen weight Immunological
Including Allergic - decrease in humoral immune response
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
6 gm/kg/60D-I
TOXIC EFFECTS :
Related to Chronic Data -
death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
300
mg/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -
phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2080
mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood -
lymphoma, including Hodgkin's disease
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2080 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic -
Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
106
mg/kg
SEX/DURATION :
female 30 week(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Fertility - pre-implantation mortality (e.g. reduction in number of implants per female;
total number of implants per corpora lutea)
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
148 gm/kg
SEX/DURATION :
female
1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn -
growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
72420 mg/kg
SEX/DURATION
:
female 1-22 day(s) after conception lactating female 30 day(s) post-birth
TOXIC
EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE
OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intravenous
DOSE :
9060 ug/kg
SEX/DURATION :
female 6-17 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity
(except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
45302 ug/kg
SEX/DURATION
:
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on
Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific
Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
10067
ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
10067
ug/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
4581
mg/kg
SEX/DURATION :
female 12-16 week(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems
(including spleen and marrow)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
30 mg/kg
SEX/DURATION :
female
8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation
mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST
:
Specific locus test
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE
OF TEST :
Dominant lethal test
MUTATION DATA
TYPE OF TEST :
DNA damage
TEST
SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
5
mmol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science,
1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 198,513,1977 ***
REVIEWS *** ACGIH TLV-TWA 0.2 mg(Mn)/m3 DTLVS* The Threshold Limit Values (TLVs) and
Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental
Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997
TOXICOLOGY REVIEW AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
Volume(issue)/page/year: TR-73-125,1973 TOXICOLOGY REVIEW ADTEAS Advances in Teratology.
(New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 5,51,1972 TOXICOLOGY
REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington,
DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Mn,121,1973 *** U.S.
STANDARDS AND REGULATIONS *** MSHA STANDARD-air:CL 5 mg(Mn)/m3 DTLVS* The Threshold Limit
Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference
of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,149,1971 OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402)
Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 5 mg(Mn)/m3 CFRGBR Code of
Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC
20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 5 mg(Mn)/m3 CFRGBR
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 5
mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL
EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN
1993 OEL-DENMARK:TWA 2.5 mg(Mn)/m3 JAN 1993 OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993
OEL-HUNGARY:TWA 0.3 mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993 OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN
1993 OEL-THE NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(Mn)/m3 JAN 1993
OEL-SWEDEN:TWA 1 mg(Mn)/m3;STEL 2.5 mg(Mn)/m3 (resp. dust) JAN 1993 OEL-SWEDEN:TWA 2.5
mg(Mn)/m3;STEL 5 mg(Mn)/m3 (total dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE,
VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH
OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS
Hazard Code - 84353 No. of Facilities: 320 (estimated) No. of Industries: 7 No. of
Occupations: 12 No. of Employees: 4916 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - 84353 No. of Facilities: 788 (estimated) No. of Industries:
6 No. of Occupations: 16 No. of Employees: 13961 (estimated) No. of Female Employees: 9451
(estimated)
