Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
OM4500000
CAS REGISTRY NUMBER
:
7487-88-9
LAST UPDATED :
199710
DATA ITEMS CITED :
25
MOLECULAR FORMULA
:
O4-S.Mg
MOLECULAR WEIGHT :
120.37
WISWESSER LINE NOTATION :
MG
S-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human -
man
DOSE/DURATION :
428 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human -
woman
DOSE/DURATION :
351 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Cardiac - arrhythmias (including changes in conduction) Blood - changes in serum composition
(e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human -
woman
DOSE/DURATION :
80 mg/kg/2M-I
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intraspinal
SPECIES OBSERVED :
Human -
woman
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation -
flaccid paralysis with appropriate anesthesia
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1029
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
645
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
48
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1200
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1500
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1
gm/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
TYPE OF TEST :
LDLo -
Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- rabbit
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
1750 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence
(general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
320
mg/kg
SEX/DURATION :
female 39 week(s) after conception
TOXIC EFFECTS
:
Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or
Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
750 mg/kg
SEX/DURATION
:
female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on
Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental
Abnormalities - hepatobiliary system
MUTATION DATA
TYPE OF TEST :
Phage inhibition
capacity
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
800
umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87.
For publisher information, see EMMUEG. Volume(issue)/page/year: 6,59,1984 *** U.S. STANDARDS
AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington,
DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT
AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National
Occupational Hazard Survey (1974) NOHS Hazard Code - 43410 No. of Facilities: 11060
(estimated) No. of Industries: 88 No. of Occupations: 80 No. of Employees: 106080
(estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 43410 No.
of Facilities: 13961 (estimated) No. of Industries: 111 No. of Occupations: 95 No. of
Employees: 235005 (estimated) No. of Female Employees: 108074 (estimated)
