Common Name	Genistein
CAS Number	446-72-0
Molecular Weight	270.237
Density	1.5±0.1 g/cm3
Boiling Point	555.5±50.0 °C at 760 mmHg
Molecular Formula	C15H10O5
Melting Point	297-298 °C
MSDS	Chinese USA
Flash Point	217.1±23.6 °C
Symbol	GHS07
Signal Word	Warning

Density	1.5±0.1 g/cm3
Boiling Point	555.5±50.0 °C at 760 mmHg
Melting Point	297-298 °C
Molecular Formula	C15H10O5
Molecular Weight	270.237
Flash Point	217.1±23.6 °C
Exact Mass	270.052826
PSA	90.90000
LogP	2.96
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.732
Storage condition	−20°C
Stability	Light Sensitive
Water Solubility	insoluble

CHEMICAL IDENTIFICATION
RTECS NUMBER :
NR2392000
CHEMICAL NAME :
Isoflavone, 4',5,7-trihydroxy-
CAS REGISTRY NUMBER :
446-72-0
BEILSTEIN REFERENCE NO. :
0263823
LAST UPDATED :
199801
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C15-H10-O5
MOLECULAR WEIGHT :
270.25
WISWESSER LINE NOTATION :
T66 BO EVT&J CR DQ& IQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
125 mg/kg
SEX/DURATION :
female 16-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
625 mg/kg
SEX/DURATION :
female 16-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1680 mg/kg
SEX/DURATION :
female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
13200 mg/kg
SEX/DURATION :
male 22 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
18600 mg/kg
SEX/DURATION :
female 31 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
MUTATION DATA
TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
25 umol/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,605,1997

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/38
Safety Phrases	S26-S24/25-S22
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NR2392000
HS Code	2932999099

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1.What is genistein?

Genistein is one of the main isoflavones found in soy. It is commonly used as a dietary supplement for its wide variety of benefits ranging from improving skin health to reducing the risk of breast cancer and possibly other types of cancer. This article is about the main benefits of genistein, its potential side effects, the best time to take it, and more.

2.What are the benefits of genistein?

1.Improved skin health – Many animal studies show promise in genistein supplementation for improving skin health. The supplement was shown to improve skin elasticity, healthy skin structure, fibroblast renewal, and dermal vascularity. It also helps the skin adapt to environmental stress. 2.Antioxidant properties – The supplement has potent antioxidant properties and can reduce damage caused by free radicals and oxidative stress. 3.Reduced inflammation – Soy isoflavones, including genistein, are anti-inflammatory and can improve various markers of inflammation in the body. 4.Improved immune health – Secondary to the antioxidant and anti-inflammatory properties, genistein can strengthen immune system health and function. This supplement can also reduce the symptoms of various autoimmune conditions. 5.Increased healthspan and lifespan – This effect hasn’t been studied directly in humans yet as the studies would be very costly and take a long time to create. However, animal studies suggest that genistein supports various mechanisms associated with healthy aging and increases in lifespan and healthspan, such as autophagy, anti-senescence mechanisms, SIRT1 signaling, AMPK signaling, and NF-κB signaling.

3.Who should not take genistein?

You should probably avoid taking genistein if you: 1.are allergic to soy or don’t tolerate it well 2.experience a severe adverse reaction after taking the supplement 3.are pregnant or breastfeeding (while it can be safe to take this supplement during pregnancy or breastfeeding, it can put some unnecessary risk to the child)

4.Who will benefit the most?

1.wish to improve general health 2.have a high budget for supplements and are willing to experiment with a variety of them (assuming you don’t fall into any of the categories that should avoid this supplement, genistein is relatively safe and unlikely to do more harm than good for most people)