Common Name	Chondroitin sulfate
CAS Number	9007-28-7
Molecular Weight	479.368
Density	2.0±0.1 g/cm3
Boiling Point	N/A
Molecular Formula	(C14H21NO14S)n
Melting Point	N/A
MSDS	N/A
Flash Point	N/A

Density	2.0±0.1 g/cm3
Molecular Formula	(C14H21NO14S)n
Molecular Weight	479.368
Exact Mass	479.058105
PSA	287.45000
LogP	-4.28
Index of Refraction	1.686
Storage condition	Store at RT.

CHEMICAL IDENTIFICATION
RTECS NUMBER :
GA8430000
CHEMICAL NAME :
Chondroitin sulfuric acids
CAS REGISTRY NUMBER :
9007-28-7
LAST UPDATED :
199701
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 6,506,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
455 gm/kg/26W-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 6,478,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1680 mg/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 14,3371,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3876 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 19 (estimated) No. of Female Employees: 19 (estimated)

Hazard Codes

T+

N/A

1.What is Chondroitin Sulfate?

Chondroitin sulfate is a chemical found in human and animal cartilage. It is commonly used by mouth with glucosamine or other ingredients for osteoarthritis. Chondroitin sulfate is one of the building blocks of cartilage. In osteoarthritis, the cartilage in the joints breaks down. Taking chondroitin sulfate might slow this breakdown. It is usually manufactured from animal sources, such as shark and cow cartilage. It can also be made in a lab. Chondroitin sulfate is used for osteoarthritis and cataracts. It is often used together with other ingredients, including manganese ascorbate, hyaluronic acid, collagen peptides, or glucosamine. Chondroitin sulfate is also used for many other conditions, but there is no good scientific evidence to support these uses.

2.What is Chondroitin Sulfate used for?

Chondroitin sulfate is used as a nutritional supplement in the treatment of osteoarthritis, an age-related degeneration of cartilage, the fibrous tissue that lines joints. Chondroitin is believed to help repair damaged cartilage, reduce joint inflammation and associated pain, swelling and stiffness. Preliminary studies indicate that chondroitin may reduce inflammation in the inner lining (endothelium) of blood vessels, and reduce the risk of plaque buildup (atherosclerosis) and consequently, the risk for heart attack (myocardial infarction).

3.How to get Chondroitin Sulfate?

Chondroitin is not available in dietary sources and can be taken only as supplements, which are available as tablets or capsules. Chondroitin has been suggested for use in many conditions other than osteoarthritis, but scientific studies for these uses are lacking. Suggested uses of chondroitin sulfate include:Osteoarthritis;.Osteoporosis;High level of blood fats (hyperlipidemia);Heart disease from impaired blood flow (ischemic heart disease);Prophylaxis for risk of myocardial infarction;Cataracts;Preterm labor;Alzheimer’s disease;Colorectal and breast cancers.

4.What are the dosages of chondroitin sulfate?

Labeling of chondroitin sulfate products may not be accurate. Consult with your healthcare provider to determine the appropriate product and dosing for you. Suggested dosing: Adult: Osteoarthritis 200-400 mg orally twice or thrice daily, OR 1000-1200 mg orally once daily Also used in combo with glucosamine Prophylaxis for recurrent myocardial infarction (MI) Initial: 10 g orally divided thrice daily for 3 months THEN Maintenance: 500 mg orally thrice daily Overdose Chondroitin sulfate overdose is unlikely to cause severe adverse reactions. Overdose may cause gastrointestinal symptoms such as stomach upset, nausea, diarrhea or constipation, which should resolve with discontinuation of chondroitin sulfate and sufficient fluid intake.