Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
EW2100000
CHEMICAL NAME :
Calcium
gluconate
CAS REGISTRY NUMBER :
299-28-5
LAST UPDATED :
199701
DATA ITEMS
CITED :
13
MOLECULAR FORMULA :
C12-H22-O14.Ca
MOLECULAR WEIGHT
:
430.42
WISWESSER LINE NOTATION :
QVYQYQYQYQ1Q 2 &-CA-
HEALTH HAZARD
DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE
OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - infant
DOSE/DURATION
:
143 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic
exposure) Nutritional and Gross Metabolic - body temperature increase
REFERENCE
:
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 129,347,1945
TYPE OF TEST
:
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES
OBSERVED :
Human - infant
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Brain and
Coverings - meningeal changes Lungs, Thorax, or Respiration - fibrosis, focal
(pneumoconiosis) Nutritional and Gross Metabolic - body temperature increase
REFERENCE
:
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 129,347,1945
TYPE OF TEST
:
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione
Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information,
see FRMCE8 Volume(issue)/page/year: 26,144,1971
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical
Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,226,1982
TYPE
OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco,
Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher
information, see FRMCE8 Volume(issue)/page/year: 26,144,1971
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
JDGRAX Journal of Drug
Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2-
1969- Volume(issue)/page/year: 15(1-2),121,1984
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2890 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American
Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For
publisher information, see JPMSAE. Volume(issue)/page/year: 45,47,1956
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Details
of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1959- Volume(issue)/page/year: 4,492,1962
TYPE OF TEST :
LDLo - Lowest
published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal
- dog
DOSE/DURATION :
1987 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and
Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
V.1- 1909/10- Volume(issue)/page/year: 47,183,1933
TYPE OF TEST :
LDLo - Lowest
published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent
- guinea pig
DOSE/DURATION :
1810 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function
of salivary glands
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et
de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
V.4- 1898- Volume(issue)/page/year: 191,44,1971 *** NIOSH STANDARDS DEVELOPMENT AND
SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational
Hazard Survey (1974) NOHS Hazard Code - 80373 No. of Facilities: 267 (estimated) No. of
Industries: 3 No. of Occupations: 11 No. of Employees: 14905 (estimated) NOES - National
Occupational Exposure Survey (1983) NOES Hazard Code - 80373 No. of Facilities: 565
(estimated) No. of Industries: 3 No. of Occupations: 16 No. of Employees: 29060 (estimated)
No. of Female Employees: 23111 (estimated)
