Common Name	Glycyrrhizic acid
CAS Number	1405-86-3
Molecular Weight	822.932
Density	1.4±0.1 g/cm3
Boiling Point	971.4±65.0 °C at 760 mmHg
Molecular Formula	C42H62O16
Melting Point	220ºC decomposes
MSDS	N/A
Flash Point	288.1±27.8 °C

Density	1.4±0.1 g/cm3
Boiling Point	971.4±65.0 °C at 760 mmHg
Melting Point	220ºC decomposes
Molecular Formula	C42H62O16
Molecular Weight	822.932
Flash Point	288.1±27.8 °C
Exact Mass	822.403809
PSA	267.04000
LogP	4.64
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.621

CHEMICAL IDENTIFICATION
RTECS NUMBER :
MD2025000
CHEMICAL NAME :
Glycyrrhizinic acid
CAS REGISTRY NUMBER :
1405-86-3
BEILSTEIN REFERENCE NO. :
0077922
LAST UPDATED :
199706
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C42-H62-O16
MOLECULAR WEIGHT :
823.04
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
280 mg/kg/4W
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - changes in phosphorus
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
662 mg/kg/1Y-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Nutritional and Gross Metabolic - changes in potassium
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4320 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
589 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
MUTATION DATA
TYPE OF TEST :
Micronucleus test
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 367,99,1996

Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
RTECS	MD2025000
HS Code	1211903600

N/A