Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
ZH5260000
CAS REGISTRY NUMBER
:
7733-02-0
LAST UPDATED :
199710
DATA ITEMS CITED :
40
MOLECULAR FORMULA
:
O4-S.Zn
MOLECULAR WEIGHT :
161.43
WISWESSER LINE NOTATION :
ZN
S-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize
test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent -
rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
45 mg/kg/7D-C
TOXIC
EFFECTS :
Cardiac - pulse rate increase, without fall in BP Gastrointestinal - other
changes Blood - normocytic anemia
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
106
mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - hypermotility,
diarrhea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
180 mg/kg/6W-I
TOXIC
EFFECTS :
Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION
:
3120 mg/kg/43W-I
TOXIC EFFECTS :
Blood - microcytosis with or without anemia
Blood - agranulocytosis Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1710 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
196
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
330
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
69900
ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
245 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29060
ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500
ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23300
ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
78
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
66
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
300
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
23
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
74 mg/kg/3D-I
TOXIC
EFFECTS :
Musculoskeletal - other changes Nutritional and Gross Metabolic - changes in
calcium
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200
mg/kg/60D-C
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic -
changes in metals, not otherwise specified
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal -
domestic
DOSE/DURATION :
7110 mg/kg/4W-I
TOXIC EFFECTS :
Gastrointestinal -
changes in structure or function of endocrine pancreas Gastrointestinal - hypermotility,
diarrhea Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
3625 ug/kg/5D-C
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
333
mg/kg
SEX/DURATION :
female 1-18 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed
implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
34573 ug/kg
SEX/DURATION
:
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female
fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant
per # females mated)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Subcutaneous
DOSE :
15 mg/kg
SEX/DURATION :
female 8 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity
(except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities -
cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
2 mg/kg
SEX/DURATION :
female
8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus -
fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
193 gm/kg
SEX/DURATION
:
female 6-20 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility -
abortion Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per
# alive at day 4)
TYPE OF TEST :
Micronucleus test
MUTATION DATA
TYPE OF TEST
:
Morphological transformation
TEST SYSTEM :
Rodent - hamster
Embryo
DOSE/DURATION :
200 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public
Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
Volume(issue)/page/year: 39,193,1979 *** REVIEWS *** TOXICOLOGY REVIEW FOREAE Food Research.
(Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
Volume(issue)/page/year: 7,313,1942 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - 77220 No. of Facilities: 3067 (estimated) No. of Industries: 52
No. of Occupations: 47 No. of Employees: 40653 (estimated) NOES - National Occupational
Exposure Survey (1983) NOES Hazard Code - 77220 No. of Facilities: 4755 (estimated) No. of
Industries: 52 No. of Occupations: 66 No. of Employees: 89451 (estimated) No. of Female
Employees: 27887 (estimated)
