Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
WB4900000
CHEMICAL NAME :
Sodium
hydroxide
CAS REGISTRY NUMBER :
1310-73-2
LAST UPDATED :
199712
DATA ITEMS
CITED :
46
MOLECULAR FORMULA :
H-Na-O
MOLECULAR WEIGHT :
40.00
WISWESSER
LINE NOTATION :
NA Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES
OBSERVED :
Primate - monkey
TYPE OF TEST :
Standard Draize test
ROUTE OF
EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE
OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the
eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize
test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent -
rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration
into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize
test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent -
rabbit
TYPE OF TEST :
Rinsed with water
ROUTE OF EXPOSURE :
Administration into
the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
Cytogenetic analysis
MUTATION
DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster
Ovary
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000
AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 225,55,1989 *** REVIEWS ***
ACGIH TLV-CL 2 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure
Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists
(ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW ARTODN
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974- Volume(issue)/page/year: 39,299,1978 *** U.S. STANDARDS AND REGULATIONS
*** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal
Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1-
1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD:air-CL 2 mg/m3 DTLVS* The
Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year: 3,233,1971 OSHA PEL (Gen Indu):8H TWA 2 mg/m3 CFRGBR Code of
Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC
20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 mg/m3 CFRGBR
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2
mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed
Cont):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 ***
OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 mg/m3 JAN 1993 OEL-BELGIUM:STEL 2 mg/m3
JAN 1993 OEL-DENMARK:TWA 2 mg/m3 JAN 1993 OEL-FINLAND:TWA 2 mg/m3 JAN 1993 OEL-FRANCE:TWA 2
mg/m3 JAN 1993 OEL-GERMANY:TWA 2 mg/m3 JAN 1993 OEL-JAPAN:STEL 2 mg/m3 JAN 1993 OEL-THE
NETHERLANDS:TWA 2 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 2 mg/m3 JAN 1993 OEL-SWEDEN:TWA 2
mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 mg/m3;STEL 4 mg/m3 JAN 1993 OEL-THAILAND:TWA 2 mg/m3
JAN 1993 OEL-TURKEY:TWA 2 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 2 mg/m3;STEL 2 mg/m3 JAN
1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE,
VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH
RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO SODIUM HYDROXIDE-air:CL 2 mg/m3/15M
REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS
#92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard
Survey (1974) NOHS Hazard Code - 69070 No. of Facilities: 112525 (estimated) No. of
Industries: 359 No. of Occupations: 192 No. of Employees: 1122583 (estimated) NOES -
National Occupational Exposure Survey (1983) NOES Hazard Code - X3782 No. of Facilities:
21989 (estimated) No. of Industries: 167 No. of Occupations: 120 No. of Employees: 370582
(estimated) No. of Female Employees: 137156 (estimated) NOES - National Occupational
Exposure Survey (1983) NOES Hazard Code - 69070 No. of Facilities: 133757 (estimated) No. of
Industries: 426 No. of Occupations: 246 No. of Employees: 2819743 (estimated) No. of Female
Employees: 995960 (estimated)
