Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
OE9800000
CHEMICAL NAME :
Lauric
acid
CAS REGISTRY NUMBER :
143-07-7
BEILSTEIN REFERENCE NO. :
1099477
LAST
UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA
:
C12-H24-O2
MOLECULAR WEIGHT :
200.36
WISWESSER LINE NOTATION
:
QV11
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize
test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent
- rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration
into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
12 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
131 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or
effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE
OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
333
gm/kg/13W-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - fluid
intake
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
108 gm/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - active as anti-cancer agent
MUTATION DATA
TYPE OF TEST :
Cytogenetic
analysis
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
DOSE/DURATION :
10
mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736) V.1- 1869- Volume(issue)/page/year: 294,263,1981 *** REVIEWS *** TOXICOLOGY REVIEW
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher
information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS
DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS -
National Occupational Hazard Survey (1974) NOHS Hazard Code - 84696 No. of Facilities: 1256
(estimated) No. of Industries: 14 No. of Occupations: 34 No. of Employees: 14960 (estimated)
NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84696 No. of
Facilities: 4690 (estimated) No. of Industries: 51 No. of Occupations: 50 No. of Employees:
77970 (estimated) No. of Female Employees: 17300 (estimated)
