Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
NO8500000
CAS REGISTRY NUMBER
:
7720-78-7
LAST UPDATED :
199712
DATA ITEMS CITED :
47
MOLECULAR FORMULA
:
O4-S.Fe
MOLECULAR WEIGHT :
151.91
WISWESSER LINE NOTATION :
FE
S-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human -
child
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Gastrointestinal - alteration in
gastric secretion Gastrointestinal - peritonitis Kidney, Ureter, Bladder - changes in
tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human -
child
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate Vascular -
BP lowering not characterized in autonomic section Gastrointestinal - nausea or
vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
390 mg/kg
TOXIC
EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - anorexia
(human) Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST
:
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Human - woman
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Behavioral -
somnolence (general depressed activity) Gastrointestinal - nausea or vomiting Kidney,
Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular
necrosis)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
4400 ug/kg
TOXIC
EFFECTS :
Behavioral - coma Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder
- changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Human - woman
DOSE/DURATION :
10560 ug/kg
TOXIC EFFECTS :
Gastrointestinal
- ulceration or bleeding from stomach
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION
:
20 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of
CNS Behavioral - somnolence (general depressed activity) Behavioral - coma
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Human - child
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Human - woman
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Behavioral
- somnolence (general depressed activity) Behavioral - aggression Gastrointestinal - nausea
or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
441
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
319 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
155
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
106
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60300
ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
112
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
79
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intraduodenal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200
mg/kg
TOXIC EFFECTS :
Cardiac - cardiac output Vascular - regional or general
arteriolar constriction Nutritional and Gross Metabolic - metabolic acidosis
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - guinea pig
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest
published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
200 ug/m3/24H/65D-C
TOXIC EFFECTS :
Brain and
Coverings - other degenerative changes Blood - changes in serum composition (e.g. TP,
bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or
tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
1600 mg/kg/16W-I
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE
:
7200 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
12153
ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Paternal Effects - testes, epididymis, sperm duct
MUTATION DATA
TYPE OF TEST
:
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
5
mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th &
Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1628,1981 ***
REVIEWS *** ACGIH TLV-TWA 1 mg(Fe)/m3 DTLVS* The Threshold Limit Values (TLVs) and
Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental
Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997
TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 4,615,1971 TOXICOLOGY REVIEW AJMEAZ
American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1-
1946- Volume(issue)/page/year: 38,409,1965 *** U.S. STANDARDS AND REGULATIONS *** MSHA
STANDARD-air:TWA 1 mg(Fe)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological
Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,138,1971 ***
OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 1 mg(Fe)/m3 JAN 1993 OEL-FINLAND:TWA 1
mg(Fe)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 1 mg(Fe)/m3 JAN 1993 OEL-SWITZERLAND:TWA 1
mg(Fe)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 1 mg(Fe)/m3;STEL 2 mg(Fe)/m3 JAN 1993 OEL IN
BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM
check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL
EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code -
33230 No. of Facilities: 2551 (estimated) No. of Industries: 29 No. of Occupations: 35 No.
of Employees: 31767 (estimated) NOES - National Occupational Exposure Survey (1983) NOES
Hazard Code - 33230 No. of Facilities: 4071 (estimated) No. of Industries: 43 No. of
Occupations: 57 No. of Employees: 85779 (estimated) No. of Female Employees: 19101
(estimated)
